Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal‐to‐Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency

H Zhang, Y Wang, ZW Hu, YW Wu, N Chen… - Advanced …, 2024 - Wiley Online Library
During maternal‐to‐zygotic transition (MZT) in the embryo, mRNA undergoes complex post‐
transcriptional regulatory processes. However, it is unclear whether and how alternative …

mRNA isoform switches during mouse zygotic genome activation

F Li, N Karimi, S Wang, T Pan, J Dong… - Cell …, 2024 - pubmed.ncbi.nlm.nih.gov
mRNA isoform switches during mouse zygotic genome activation mRNA isoform switches
during mouse zygotic genome activation Cell Prolif. 2024 May 19:e13655. doi: 10.1111/cpr.13655 …

[HTML][HTML] Transcriptome Responses to Different Salinity Conditions in Litoditis marina, Revealed by Long-Read Sequencing

P Zhang, B Xue, H Yang, L Zhang - Genes, 2024 - mdpi.com
The marine nematode Litoditis marina is widely distributed in intertidal zones around the
globe, yet the mechanisms underlying its broad adaptation to salinity remain elusive. In this …

[HTML][HTML] Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotype and phenotype in chronic lymphocytic leukemia

GS Black, X Huang, Y Qiao, P Moos, D Sampath… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Bruton's tyrosine kinase (BTK) inhibitors are effective for the treatment of chronic lymphocytic
leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is …

Long-read RNA sequencing identifies region-and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage

EF Jones, TC Howton, VL Flanary, AD Clark… - bioRxiv, 2024 - biorxiv.org
Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes,
tissues, and cell types. Many diseases are either caused by alterations in AS or by …