Small molecule kinase inhibitor drugs (1995–2021): medical indication, pharmacology, and synthesis
CC Ayala-Aguilera, T Valero… - Journal of Medicinal …, 2021 - ACS Publications
The central role of dysregulated kinase activity in the etiology of progressive disorders,
including cancer, has fostered incremental efforts on drug discovery programs over the past …
including cancer, has fostered incremental efforts on drug discovery programs over the past …
[HTML][HTML] Impact of COVID-19 on clinical trials and clinical research: a systematic review
Background: The World Health Organization has reported more than 31,186,000 confirmed
cases of coronavirus disease-19 (COVID-19), including 962,343 deaths, worldwide as on …
cases of coronavirus disease-19 (COVID-19), including 962,343 deaths, worldwide as on …
Five-year extension results of the phase 1 START trial of onasemnogene abeparvovec in spinal muscular atrophy
JR Mendell, SA Al-Zaidy, KJ Lehman, M McColly… - JAMA …, 2021 - jamanetwork.com
Importance This ongoing study assesses long-term safety and durability of response in
infants with spinal muscular atrophy (SMA) type 1 after dosing with onasemnogene …
infants with spinal muscular atrophy (SMA) type 1 after dosing with onasemnogene …
Impact of the COVID-19 pandemic on publication dynamics and non-COVID-19 research production
M Raynaud, V Goutaudier, K Louis, S Al-Awadhi… - BMC medical research …, 2021 - Springer
Background The COVID-19 pandemic has severely affected health systems and medical
research worldwide but its impact on the global publication dynamics and non-COVID-19 …
research worldwide but its impact on the global publication dynamics and non-COVID-19 …
Cancer care disruption and reorganisation during the COVID-19 pandemic in Australia: a patient, carer and healthcare worker perspective
R Edge, J Meyers, G Tiernan, Z Li, A Schiavuzzi… - PLoS …, 2021 - journals.plos.org
The COVID-19 pandemic has dramatically impacted cancer care worldwide. Disruptions
have been seen across all facets of care. While the long-term impact of COVID-19 remains …
have been seen across all facets of care. While the long-term impact of COVID-19 remains …
[HTML][HTML] Decentralised clinical trials: ethical opportunities and challenges
E Vayena, A Blasimme, J Sugarman - The Lancet Digital Health, 2023 - thelancet.com
Fuelled by adaptations to clinical trial implementation during the COVID-19 pandemic,
decentralised clinical trials are burgeoning. Decentralised clinical trials involve many digital …
decentralised clinical trials are burgeoning. Decentralised clinical trials involve many digital …
[HTML][HTML] Learning deep neural networks' architectures using differential evolution. Case study: medical imaging processing
S Belciug - Computers in Biology and Medicine, 2022 - Elsevier
The COVID-19 pandemic has changed the way we practice medicine. Cancer patient and
obstetric care landscapes have been distorted. Delaying cancer diagnosis or maternal-fetal …
obstetric care landscapes have been distorted. Delaying cancer diagnosis or maternal-fetal …
[HTML][HTML] Research and management of rare diseases in the COVID-19 pandemic era: challenges and countermeasures
The ongoing coronavirus disease 2019 (COVID-19) pandemic has disrupted every aspect of
our life. The need to provide high-level care for an enormous number of patients with COVID …
our life. The need to provide high-level care for an enormous number of patients with COVID …
[HTML][HTML] The impact of COVID-19 on cancer care and oncology clinical research: an experts' perspective
C Sessa, J Cortes, P Conte, F Cardoso, T Choueiri… - Esmo Open, 2022 - Elsevier
The coronavirus disease-19 (COVID-19) pandemic promises to have lasting impacts on
cancer clinical trials that could lead to faster patient access to new treatments. In this article …
cancer clinical trials that could lead to faster patient access to new treatments. In this article …
[HTML][HTML] Therapeutic potential of exploiting autophagy cascade against coronavirus infection
Since its emergence in December 2019 in Wuhan, China, severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) created a worldwide pandemic of coronavirus …
syndrome coronavirus 2 (SARS-CoV-2) created a worldwide pandemic of coronavirus …