Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …

Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

The biochemical role of the PI3K/PKB/mTOR signalling pathway in cell-cycle regulation is
now well known. During the onset and development of different forms of cancer it becomes …

The global prevalence of nonalcoholic fatty liver disease (NAFLD) continues to rise, yet
effective treatments are lacking due to the complex pathogenesis of this disease. Although …

The PI3K-Akt-mTOR pathway is a viable target for cancer treatment and can be used to treat
various malignant tumours, including follicular lymphoma and breast cancer. Both enzymes …

As a substrate and major effector of the mammalian target of rapamycin complex 1
(mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been …

CD8+ T cells are the key executioners of the adaptive immune arm, which mediates
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …

Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk
with other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple …