[HTML][HTML] COVID-19 challenges and its therapeutics

SU Rehman, SU Rehman, HH Yoo - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract COVID-19, an infectious disease, has emerged as one of the leading causes of
death worldwide, making it one of the severe public health issues in recent decades. nCoV …

[HTML][HTML] Hydroxychloroquine in the treatment of COVID-19: a multicenter randomized controlled study

S Abd-Elsalam, ES Esmail, M Khalaf… - The American journal …, 2020 - ncbi.nlm.nih.gov
The COVID-19 pandemic is showing an exponential growth, mandating an urgent need to
develop an effective treatment. Indeed, to date, a well-established therapy is still lacking. We …

QT prolongation, torsades de pointes, and sudden death with short courses of chloroquine or hydroxychloroquine as used in COVID-19: A systematic review

L Jankelson, G Karam, ML Becker, LA Chinitz, MC Tsai - Heart rhythm, 2020 - Elsevier
Chloroquine and hydroxychloroquine are now being widely used for treatment of COVID-19.
Both medications prolong the QT interval and accordingly may put patients at increased risk …

AI-based language models powering drug discovery and development

Z Liu, RA Roberts, M Lal-Nag, X Chen, R Huang… - Drug Discovery …, 2021 - Elsevier
The discovery and development of new medicines is expensive, time-consuming, and often
inefficient, with many failures along the way. Powered by artificial intelligence (AI), language …

A snapshot of the global race for vaccines targeting SARS-CoV-2 and the COVID-19 pandemic

CD Funk, C Laferrière, A Ardakani - Frontiers in pharmacology, 2020 - frontiersin.org
A novel coronavirus SARS-CoV-2 causing Coronavirus disease 2019 (COVID-19) has
entered the human population and has spread rapidly around the world in the first half of …

Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis

MS Kim, MH An, WJ Kim, TH Hwang - PLoS medicine, 2020 - journals.plos.org
Background Numerous clinical trials and observational studies have investigated various
pharmacological agents as potential treatment for Coronavirus Disease 2019 (COVID-19) …

Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis

Z Kashour, M Riaz, MA Garbati… - Journal of …, 2021 - academic.oup.com
Objectives Clinical studies of chloroquine (CQ) and hydroxychloroquine (HCQ) in COVID-19
disease reported conflicting results. We sought to systematically evaluate the effect of CQ …

[HTML][HTML] Immunology of COVID-19: current state of the science

N Vabret, GJ Britton, C Gruber, S Hegde, J Kim… - Immunity, 2020 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting …

Multicenter interim guidance on use of antivirals for children with coronavirus disease 2019/severe acute respiratory syndrome coronavirus 2

K Chiotos, M Hayes, DW Kimberlin… - Journal of the …, 2021 - academic.oup.com
Background Although coronavirus disease 2019 (COVID-19) is a mild infection in most
children, a small proportion develop severe or critical illness. Data describing agents with …

[HTML][HTML] The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro

J Song, L Zhang, Y Xu, D Yang, S Yang… - Biochemical …, 2021 - Elsevier
Baicalein is the main active compound of Scutellaria baicalensis Georgi, a medicinal herb
with multiple pharmacological activities, including the broad anti-virus effects. In this paper …