Role of interferon therapy in severe COVID-19: the COVIFERON randomized controlled trial

I Alavi Darazam, S Shokouhi, MA Pourhoseingholi… - Scientific reports, 2021 - nature.com
Abstract Type 1 Interferons (IFNs) have been associated with positive effects on
Coronaviruses. Previous studies point towards the superior potency of IFNβ compared to …

A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS …

KS Kim, K Ejima, S Iwanami, Y Fujita, H Ohashi… - PLoS …, 2021 - journals.plos.org
The scientific community is focused on developing antiviral therapies to mitigate the impacts
of the ongoing novel coronavirus disease 2019 (COVID-19) outbreak. This will be facilitated …

Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets

R Li, Y Li, X Liang, L Yang, M Su… - Briefings in …, 2021 - academic.oup.com
Objectives Patients with colorectal cancer (CRC) may be susceptible to the coronavirus
disease-2019 (COVID-19). However, anti-CRC/COVID-19 treatment options are currently …

Chloroquine and hydroxychloroquine for the treatment of COVID-19: a systematic review and meta-analysis

A Elavarasi, M Prasad, T Seth, RK Sahoo… - Journal of general …, 2020 - Springer
Background There is no effective therapy for COVID-19. Hydroxychloroquine (HCQ) and
chloroquine (CQ) have been used for its treatment but their safety and efficacy remain …

[HTML][HTML] Rethinking the role of hydroxychloroquine in the treatment of COVID‐19

EA Meyerowitz, AGL Vannier, MGN Friesen… - The FASEB …, 2020 - ncbi.nlm.nih.gov
There are currently no proven or approved treatments for coronavirus disease 2019 (COVID‐
19). Early anecdotal reports and limited in vitro data led to the significant uptake of …

Multicenter initial guidance on use of antivirals for children with coronavirus disease 2019/severe acute respiratory syndrome coronavirus 2

K Chiotos, M Hayes, DW Kimberlin… - Journal of the …, 2020 - academic.oup.com
Background Although coronavirus disease 2019 (COVID-19) is mild in nearly all children, a
small proportion of pediatric patients develop severe or critical illness. Guidance is therefore …

COVID-19 in patients with rheumatic disease in Hubei province, China: a multicentre retrospective observational study

J Zhong, G Shen, H Yang, A Huang, X Chen… - The Lancet …, 2020 - thelancet.com
Background In the ongoing COVID-19 pandemic, the susceptibility of patients with rheumatic
diseases to COVID-19 remains unclear. We aimed to investigate susceptibility to COVID-19 …

Novel insights on the pulmonary vascular consequences of COVID-19

F Potus, V Mai, M Lebret, S Malenfant… - … of Physiology-Lung …, 2020 - journals.physiology.org
In the last few months, the number of cases of a new coronavirus-related disease (COVID-
19) rose exponentially, reaching the status of a pandemic. Interestingly, early imaging …

A randomized, open‐label, controlled clinical trial of azvudine tablets in the treatment of mild and common COVID‐19, a pilot study

Z Ren, H Luo, Z Yu, J Song, L Liang, L Wang… - Advanced …, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) has spread worldwide. To date, no specific
drug for COVID‐19 has been developed. Thus, this randomized, open‐label, controlled …

Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

D Huang, H Yu, T Wang, H Yang… - Journal of medical …, 2021 - Wiley Online Library
We conducted this systemic review and meta‐analysis in an attempt to evaluate the efficacy
and safety of umifenovir in coronavirus disease 2019 (COVID‐19). We searched PubMed …