The role of retrotransposable elements in ageing and age-associated diseases
The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …
the activity of transposable elements (transposons). Transposons are mobile genetic …
DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
Transposable elements shape the evolution of mammalian development
AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Mechanisms of enhancer action: the known and the unknown
A Panigrahi, BW O'Malley - Genome biology, 2021 - Springer
Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
RepeatModeler2 for automated genomic discovery of transposable element families
The accelerating pace of genome sequencing throughout the tree of life is driving the need
for improved unsupervised annotation of genome components such as transposable …
for improved unsupervised annotation of genome components such as transposable …
[HTML][HTML] IntegronFinder 2.0: identification and analysis of integrons across bacteria, with a focus on antibiotic resistance in Klebsiella
Integrons are flexible gene-exchanging platforms that contain multiple cassettes encoding
accessory genes whose order is shuffled by a specific integrase. Integrons embedded within …
accessory genes whose order is shuffled by a specific integrase. Integrons embedded within …
A field guide to eukaryotic transposable elements
JN Wells, C Feschotte - Annual review of genetics, 2020 - annualreviews.org
Transposable elements (TEs) are mobile DNA sequences that propagate within genomes.
Through diverse invasion strategies, TEs have come to occupy a substantial fraction of …
Through diverse invasion strategies, TEs have come to occupy a substantial fraction of …
Transposable elements in mammalian chromatin organization
Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …
mammalian genomic sequence. TEs are capable of making additional copies of themselves …