Histone lysine-specific demethylase 1 (LSD1/KDM1A) has become an important and
promising anticancer target since it was first identified in 2004 and specially demethylates …

A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …

In skeletal muscle, asymmetrically dividing satellite stem cells give rise to committed satellite
cells that transcribe the myogenic determination factor Myf5, a Pax7-target gene. We …

Overexpression of MYC is a hallmark of many human cancers. The MYC oncogene has long
been thought to execute its neoplastic functions by acting as a classic transcription factor …

It is well-established that Lysine-specific demethylase 1 (LSD1, also known as KDM1A)
roles as a lysine demethylase canonically acting on H3K4me1/2 and H3K9me1/2 for …

Chromatin modifications are linked with regulating patterns of gene expression, but their
causal role and context-dependent impact on transcription remains unresolved. Here we …

Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …

Summary p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53
signaling. Although 53BP1's function is well established in DNA double-strand break repair …

Estrogen receptor α (ER) is a ligand-dependent transcription factor. Upon binding estrogen,
ER recruits coactivator complexes with histone acetyltransferase or methyltransferase …

Bladder cancer is approximately three times more common in men as compared to women.
We and others have previously investigated the contribution of androgens and the androgen …