By David R. Phillips, Israel F. Charo, Leslie V. Parise, and Laurence A. Fitzgerald A NEW
FAMILY of cell-surface receptors has been identified that mediates a wide variety of cell-cell …

Platelets are discoidal cytoplasmic particles that respond to a variety of stimuli by developing
filopodia and rounding up (shape change), developing the ability to bind fibrinogen from the …

We have identified two distinct mechanisms initiating the adhesion of flowing platelets to
thrombogenic surfaces. The integrin α IIb β 3 promotes immediate arrest onto fibrinogen but …

Platelet activation is accompanied by the appearance on the platelet surface of
approximately 45,000 receptor sites for fibrinogen. The binding of fibrinogen to these …

We describe the isolation, characterization, and sequence of cDNA clones encoding one
subunit of the complex of membrane glycoproteins that forms part of the transmembrane …

Exposure of platelets to shear stress leads to aggregation in the absence of exogenous
agonists. We have now found that different adhesive proteins and platelet membrane …

Enclothelial cells and activated platelets express integrin-type receptors responsible for
adhesion to fibrinogen. We have located distinct integrin-directed endothelial cell and …

Rearrangements of membrane glycoproteins are believed to occur during platelet activation,
but these changes have not been well defined. We have developed a monoclonal antibody …

Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function
relationship of peptides corresponding Page 1 Biochemistry 1984, 23, 1767-1774 1767 …

We demonstrate that unstimulated platelets attach to immobilized fibrinogen in a selective
process mediated by the membrane glycoprotein (GP) complex IIb-IIIa (alpha IIb beta 3). The …