Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses

NS Chapman, RJG Hulswit, JLB Westover… - Nature …, 2023 - nature.com
Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans
and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a …

[HTML][HTML] SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes

SC Wall, N Suryadevara, C Kim, AR Shiakolas… - Cell Reports …, 2023 - cell.com
From the beginning of the COVID-19 pandemic, children have exhibited different
susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors

R Jimmidi, S Chamakuri, S Lu, MN Ucisik… - Communications …, 2023 - nature.com
The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of
COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of …

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

TB Engdahl, E Binshtein, RL Brocato, NA Kuzmina… - Elife, 2023 - elifesciences.org
Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to
humans by aerosolized excreta or, in rare cases, person-to-person contact. While infections …

Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody

R Stass, TB Engdahl, NS Chapman, RM Wolters… - Nature …, 2023 - nature.com
Rodent-borne hantaviruses are prevalent worldwide and upon spillover to human
populations, cause severe disease for which no specific treatment is available. A potent …

Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies

N Suryadevara, AR Otrelo-Cardoso, N Kose… - Nature …, 2024 - nature.com
Human parainfluenza virus type 3 (hPIV3) is a respiratory pathogen that can cause severe
disease in older people and infants. Currently, vaccines against hPIV3 are in clinical trials …

[HTML][HTML] Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody

NV Johnson, SC Wall, KJ Kramer, CM Holt… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Three coronaviruses have spilled over from animal reservoirs into the human population
and caused deadly epidemics or pandemics. The continued emergence of coronaviruses …

Real-Time Analysis of SARS-CoV-2-Induced Cytolysis Reveals Distinct Variant-Specific Replication Profiles

SE Scheuermann, K Goff, LA Rowe, BJ Beddingfield… - Viruses, 2023 - mdpi.com
The ability of each new SARS-CoV-2 variant to evade host humoral immunity is the focus of
intense research. Each variant may also harbor unique replication capabilities relevant for …

Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface

RM Wolters, JA Ferguson, IA Nuñez, EE Chen… - Immunity, 2024 - cell.com
Influenza B viruses (IBVs) comprise a substantial portion of the circulating seasonal human
influenza viruses. Here, we describe the isolation of human monoclonal antibodies (mAbs) …