[HTML][HTML] Therapeutic potential of pro-resolving mediators in diabetic kidney disease

T Vartak, C Godson, E Brennan - Advanced drug delivery reviews, 2021 - Elsevier
Renal microvascular disease associated with diabetes [Diabetic kidney disease-DKD] is the
leading cause of chronic kidney disease. In DKD, glomerular basement membrane …

DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney disease

LJ Smyth, GJ McKay, AP Maxwell, AJ McKnight - Epigenetics, 2014 - Taylor & Francis
Genetic risk factors for chronic kidney disease (CKD) are being identified through
international collaborations. By comparison, epigenetic risk factors for CKD have only …

Insights into kidney diseases from genome-wide association studies

M Wuttke, A Köttgen - Nature Reviews Nephrology, 2016 - nature.com
Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

Genetic and epigenetic studies in diabetic kidney disease

HF Gu - Frontiers in genetics, 2019 - frontiersin.org
Chronic kidney disease is a worldwide health crisis, while diabetic kidney disease (DKD)
has become the leading cause of end-stage renal disease (ESRD). DKD is a microvascular …

Plasma PFOA and PFOS levels, DNA methylation, and blood lipid levels: a pilot study

X Cheng, Y Wei, Z Zhang, F Wang, J He… - Environmental …, 2022 - ACS Publications
Exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) is
associated with blood lipids in adults, but the underlying mechanisms remain unclear. This …

A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances

H Tutunchi, A Ostadrahimi… - Obesity …, 2020 - Wiley Online Library
Summary Neuregulin 4 (Nrg4), a novel brown fat–enriched hormone, plays a key role in the
modulation of glucose and lipid metabolism and energy balance. Recent data have …

The genetic map of diabetic nephropathy: evidence from a systematic review and meta-analysis of genetic association studies

M Tziastoudi, I Stefanidis, E Zintzaras - Clinical kidney journal, 2020 - academic.oup.com
Despite the extensive efforts of scientists, the genetic background of diabetic nephropathy
(DN) has not yet been clarified. To elucidate the genetic variants that predispose to the …

Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

C Gluck, C Qiu, SY Han, M Palmer, J Park… - Nature …, 2019 - nature.com
Epigenetic changes might provide the biological explanation for the long-lasting impact of
metabolic alterations of diabetic kidney disease development. Here we examined cytosine …

Depression associated with diabetes: from pathophysiology to treatment

J Menezes Zanoveli, H de Morais… - Current diabetes …, 2016 - ingentaconnect.com
Diabetes is a chronic and progressive syndrome commonly associated with several
neuropsychiatric comorbities, of which depression is the most studied. The prevalence of …

Mechanisms of the multitasking endothelial protein NRG-1 as a compensatory factor during chronic heart failure

GW De Keulenaer, E Feyen, L Dugaucquier… - Circulation: Heart …, 2019 - Am Heart Assoc
Heart failure is a complex syndrome whose phenotypic presentation and disease
progression depends on a complex network of adaptive and maladaptive responses. One of …