New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …

The effectiveness of β-lactam antibiotics is increasingly influenced by serine β-lactamases
(SBLs) and metallo-β-lactamases (MBLs), which can hydrolyze β-lactam antibiotics. The …

Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to
carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to …

Resistant bacteria represent an urgent worldwide threat. NDM-1-producing strains are
rendering the last line antibiotics less effective. Six bismuth complexes of general formula …

Abstract Metallo-β-lactamases (MBLs) are important contributors of Gram-negative bacteria
resistance to β-lactam antibiotics. MBLs are highly worrying because of their …

In Gram-negative bacteria, the major mechanism of resistance to β-lactam antibiotics is the
production of one or several β-lactamases (BLs), including the highly worrying …

ABSTRACT Introduction Metallo-β-lactamases (MBLs) are enzymes produced by bacteria
that confer resistance to most β-lactam antibiotics, including carbapenems, which have the …

Antibacterial resistance towards the β-lactam (BL) drugs is now ubiquitous, and there is a
major global health concern associated with the emergence of new β-lactamases (BLAs) as …

Multidrug bacterial resistance endangers clinically effective antimicrobial therapy and
continues to cause major public health problems, which have been upgraded to …

The treatment of infectious diseases is a challenging issue faced by the medical community.
The emergence of drug-resistant strains of bacteria and fungi is a major concern …