Advances in immunotherapy for triple-negative breast cancer

Y Liu, Y Hu, J Xue, J Li, J Yi, J Bu, Z Zhang, P Qiu… - Molecular cancer, 2023 - Springer
Background Immunotherapy has recently emerged as a treatment strategy which stimulates
the human immune system to kill tumor cells. Tumor immunotherapy is based on immune …

Immune checkpoint inhibitor resistance in hepatocellular carcinoma

Z Wang, Y Wang, P Gao, J Ding - Cancer letters, 2023 - Elsevier
The application of immune checkpoint inhibitors (ICIs) has markedly enhanced the treatment
of hepatocellular carcinoma (HCC), and HCC patients who respond to ICIs have shown …

[HTML][HTML] Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Z Wan, J Zheng, Z Zhu, L Sang, J Zhu, S Luo… - Frontiers in …, 2022 - frontiersin.org
Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from
the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As …

Causal effects of specific gut microbiota on chronic kidney diseases and renal function—a two-sample Mendelian randomization study

N Li, Y Wang, P Wei, Y Min, M Yu, G Zhou, G Yuan… - Nutrients, 2023 - mdpi.com
Background: Targeting the gut microbiota may become a new therapeutic to prevent and
delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship …

Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell

X Zhu, K Li, G Liu, R Wu, Y Zhang, S Wang, M Xu… - Gut …, 2023 - Taylor & Francis
Recent studies have demonstrated that the antitumor immunity of immune cells can be
modulated by gut microbiota and their metabolites. However, the underlying mechanisms …

Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy

J Sun, F Chen, G Wu - The ISME Journal, 2023 - academic.oup.com
The symbiotic bacteria that live in the human gut and the metabolites they produce have
long influenced local and systemic physiological and pathological processes of the host …

Cancer resistance to immunotherapy: comprehensive insights with future perspectives

SS Said, WN Ibrahim - Pharmaceutics, 2023 - mdpi.com
Cancer immunotherapy is a type of treatment that harnesses the power of the immune
systems of patients to target cancer cells with better precision compared to traditional …

Liquid biopsy on the horizon in immunotherapy of non-small cell lung cancer: current status, challenges, and perspectives

Y Yang, H Liu, Y Chen, N Xiao, Z Zheng, H Liu… - Cell Death & …, 2023 - nature.com
Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human
health and life. In most cases, patients with NSCLC are already at an advanced stage when …

The hippo pathway effectors YAP/TAZ-TEAD oncoproteins as emerging therapeutic targets in the tumor microenvironment

RB Mokhtari, N Ashayeri, L Baghaie, M Sambi, K Satari… - Cancers, 2023 - mdpi.com
Simple Summary YAP/TAZ are the central effectors of the Hippo pathway and orchestrate
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …

Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target

M Zhang, J Liu, Q Xia - Experimental Hematology & Oncology, 2023 - Springer
Immunotherapy has emerged as an effective treatment for various types of cancers. Recent
studies have highlighted a significant correlation between the gut microbiome and patients' …