Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Simple Summary Some regions of aggressive malignancies experience hypoxia due to
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …

We address a mathematical model for oxygen transfer in the microcirculation. The model
includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen …

Purpose Tumor oxygenation is one of the key features influencing the response of cells to
radiation and chemo therapies. This study presents a novel in silico tumor model simulating …

Nitroimidazoles are one of the most common radiosensitizers investigated to combat
hypoxia-induced resistance to cancer radiotherapy. However, due to poor selectivity …

Introduction The increased radioresistance of hypoxic cells compared to well-oxygenated
cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA …

The precursor of Co metal organic framework (MOF) was first synthesized by hydrothermal
method; then, the optimal Co-MOF was pyrolyzed in a nitrogen atmosphere to obtain the …

Exosomes, which are tiny particles released by cells, have the ability to transport various
molecules, including proteins, lipids, and genetic material containing non-coding RNAs …

Tumor behavior is determined by its interaction with the tumor microenvironment (TME).
Chimeric antigen receptor (CART) cell therapy represents a new form of cellular …

Radiotherapy (RT) is a traditional therapeutic regime that focuses on ionizing radiation,
however, RT maintains largely palliative due to radioresistance. Factors such as hypoxia …