WNT signalling in the immune system: WNT is spreading its wings
WNT proteins are secreted morphogens that are required for basic developmental
processes, such as cell-fate specification, progenitor-cell proliferation and the control of …
processes, such as cell-fate specification, progenitor-cell proliferation and the control of …
Prodrugs of phosphonates and phosphates: crossing the membrane barrier
A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …
Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures
S Ruiz García, M Deprez, K Lebrigand… - …, 2019 - journals.biologists.com
The upper airway epithelium, which is mainly composed of multiciliated, goblet, club and
basal cells, ensures proper mucociliary function and can regenerate in response to assaults …
basal cells, ensures proper mucociliary function and can regenerate in response to assaults …
[PDF][PDF] Grading the neuroendocrine tumors of the lung: an evidence-based proposal
The ability of oestrogens and androgens to stimulate the growth of a number of endocrine
cancers is well established and several endocrine therapies are widely used to reduce the …
cancers is well established and several endocrine therapies are widely used to reduce the …
[HTML][HTML] The role of pontin and reptin in cellular physiology and cancer etiology
YQ Mao, WA Houry - Frontiers in molecular biosciences, 2017 - frontiersin.org
Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors
H Wang, B Li, L Zuo, B Wang, Y Yan, K Tian… - Nature …, 2022 - nature.com
Abstract RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
[PDF][PDF] Negative regulation of hypoxic responses via induced Reptin methylation
Lysine methylation within histones is crucial for transcriptional regulation and thus links
chromatin states to biological outcomes. Although recent studies have extended lysine …
chromatin states to biological outcomes. Although recent studies have extended lysine …
Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia
Inherited peripheral neuropathies are frequent neuromuscular disorders known for their
clinical and genetic heterogeneity. In 33 families, we identified 8 mutations in HINT1 …
clinical and genetic heterogeneity. In 33 families, we identified 8 mutations in HINT1 …
HINT1 (histidine triad nucleotide-binding protein 1) attenuates cardiac hypertrophy via suppressing HOXA5 (homeobox A5) expression
Y Zhang, Q Da, S Cao, K Yan, Z Shi, Q Miao, C Li… - Circulation, 2021 - Am Heart Assoc
Background: Cardiac hypertrophy is an important prepathology of, and will ultimately lead to,
heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain …
heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain …