The preterm parturition syndrome

R Romero, J Espinoza, JP Kusanovic… - … Journal of Obstetrics …, 2006 - Wiley Online Library
The implicit paradigm that has governed the study and clinical management of preterm
labour is that term and preterm parturition are the same processes, except for the gestational …

The role of inflammation and infection in preterm birth

R Romero, J Espinoza, LF Gonçalves… - Seminars in …, 2007 - thieme-connect.com
Inflammation has been implicated in the mechanisms responsible for preterm and term
parturition, as well as fetal injury. Out of all of the suspected causes of preterm labor and …

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

R Romero, J Miranda, P Chaemsaithong… - The journal of …, 2015 - Taylor & Francis
Objective: The objectives of this study were to:(1) determine the amniotic fluid (AF)
microbiology of patients with preterm prelabor rupture of membranes (PROM); and (2) …

Cytokines, prostaglandins and parturition—a review

JA Keelan, M Blumenstein, RJA Helliwell, TA Sato… - Placenta, 2003 - Elsevier
The elaboration of cytokines, chemokines and immunomodulatory proteins in the placenta
and gestational membranes has been extensively investigated in the context of both normal …

Spontaneous preterm birth: advances toward the discovery of genetic predisposition

JF Strauss III, R Romero, N Gomez-Lopez… - American journal of …, 2018 - Elsevier
Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …

A novel molecular microbiologic technique for the rapid diagnosis of microbial invasion of the amniotic cavity and intra‐amniotic infection in preterm labor with intact …

R Romero, J Miranda… - American journal of …, 2014 - Wiley Online Library
Problem The diagnosis of microbial invasion of the amniotic cavity (MIAC) has been
traditionally performed using traditional cultivation techniques, which require growth of …

Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition

JM Bowen, L Chamley, JA Keelan, MD Mitchell - Placenta, 2002 - Elsevier
In an earlier, companion, review, we concluded that cytokines produced by the placenta and
associated membranes are likely to be involved in control of the processes of implantation …

Cytokines of the placenta and extra-placental membranes: biosynthesis, secretion and roles in establishment of pregnancy in women

JM Bowen, L Chamley, MD Mitchell, JA Keelan - Placenta, 2002 - Elsevier
Virtually all known cytokines have been demonstrated to be expressed in the placenta and
associated fetal and maternal membranes during normal gestation. In addition to playing …

Infection and the role of inflammation in preterm premature rupture of the membranes

R Menon, SJ Fortunato - Best practice & research Clinical obstetrics & …, 2007 - Elsevier
Spontaneous preterm birth, caused by preterm labor (contractions before 37 weeks'
gestation) or preterm premature rupture of the membranes (pPROM)(membrane rupture …

Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes

M Kacerovsky, R Romero, M Stepan, J Stranik… - American journal of …, 2020 - Elsevier
Background Preterm prelabor rupture of the membranes (PPROM) is frequently complicated
by intraamniotic inflammatory processes such as intraamniotic infection and sterile …