[HTML][HTML] Ruthenium-nitrosyl complexes as NO-releasing molecules, potential anticancer drugs, and photoswitches based on linkage isomerism

I Stepanenko, M Zalibera, D Schaniel, J Telser… - Dalton …, 2022 - pubs.rsc.org
The synthesis of new types of mono-and polynuclear ruthenium nitrosyl complexes is driving
progress in the field of NO generation for a variety of applications. Light-induced Ru-NO …

Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents

V Brabec, J Kasparkova - Coordination chemistry reviews, 2018 - Elsevier
Ruthenium complexes exhibit a broad variety of biological and biomedical activities
including anticancer efficiency. The reason is that the octahedral bonding of both Ru (II) and …

Fe in biosynthesis, translocation, and signal transduction of NO: toward bioinorganic engineering of dinitrosyl iron complexes into NO-delivery scaffolds for tissue …

HY Hsiao, CW Chung, JH Santos, OB Villaflores… - Dalton …, 2019 - pubs.rsc.org
Iron, the most abundant transition metal ion in humans, participates in the biosynthesis,
translocation, signal transduction, and transformation of nitric oxide through its …

Bioinorganic systems responsive to the diatomic gases O2, NO, and CO: From biological sensors to therapy

LG de Franca Lopes, FSG Júnior, AKM Holanda… - Coordination Chemistry …, 2021 - Elsevier
The diatomic molecules, O 2, NO and CO, have had a myriad of roles in biology. Due to this,
nature has developed many sensing proteins to perceive and respond to changes in the …

[HTML][HTML] The biofilm inhibition activity of a NO donor nanosilica with enhanced antibiotics action

PM da Silva Filho, AL Andrade, JBAC Lopes… - International Journal of …, 2021 - Elsevier
Nitric oxide (NO) has emerged as a promising antibacterial agent, where NO donor
compounds have been explored. Here, we investigated the role of a silica nanoparticle …

Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities

GL Sasahara, FSG Júnior… - Journal of Inorganic …, 2020 - Elsevier
Inflammation is a physiological process triggered in response to tissue damage, and
involves events related to cell recruitment, cytokines release and reactive oxygen species …

When NO. Is not Enough: Chemical Systems, Advances and Challenges in the Development of NO. and HNO Donors for Old and Current Medical Issues

E Muniz Carvalho, EH Silva Sousa… - European Journal of …, 2021 - Wiley Online Library
Nitric oxide (NO.) has been widely studied as an active agent of many physiological and
pathological processes. Currently, NO. divides attention with its sibling molecule, nitroxyl …

New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

FSG Júnior, JA de Moraes Silveira, TM Holanda… - Dalton …, 2023 - pubs.rsc.org
Nitrosyl ruthenium complexes are promising platforms for nitric oxide (NO) and nitroxyl
(HNO) release, which exert their therapeutic application. In this context, we developed two …

An unusual bidentate methionine ruthenium (II) complex: photo-uncaging and antimicrobial activity

AP de Sousa, ACS Gondim, EHS Sousa… - JBIC Journal of …, 2020 - Springer
Abstract The cis-[Ru (bpy) 2 (Met)](PF 6) 2 complex, where Met= l-methionine and bpy= 2,
2′-bipyridine, was prepared and fully characterized. This complex was subjected to blue …

Reactivity of a nitrosyl ruthenium complex and its potential impact on the fate of DNA–An in vitro investigation

PHR Martins, AIB Romo, FON da Silva… - Journal of Inorganic …, 2023 - Elsevier
The role of metal complexes on facing DNA has been a topic of major interest. However,
metallonitrosyl compounds have been poorly investigated regarding their reactivities and …