Omicron BA. 4/BA. 5 escape neutralizing immunity elicited by BA. 1 infection

K Khan, F Karim, Y Ganga, M Bernstein, Z Jule… - Nature …, 2022 - nature.com
Abstract SARS-CoV-2 Omicron (B. 1.1. 529) BA. 4 and BA. 5 sub-lineages, first detected in
South Africa, have changes relative to Omicron BA. 1 including substitutions in the spike …

Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

MM Painter, TS Johnston, KA Lundgreen… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated
individuals is increasingly common but rarely results in severe disease, likely due to the …

Dissecting the Protective Effect of CD8+ T Cells in Response to SARS-CoV-2 mRNA Vaccination and the Potential Link with Lymph Node CD8+ T Cells

M Chen, V Venturi, CML Munier - Biology, 2023 - mdpi.com
Simple Summary Coronavirus disease 2019 (COVID-19) is a respiratory disease caused by
the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants

TS Johnston, SH Li, MM Painter, RK Atkinson… - Immunity, 2024 - cell.com
The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
continues to accumulate substitutions, leading to breakthrough infections of vaccinated …

Covid-19: is omicron less lethal than delta?

R Lorenzo-Redondo, EA Ozer, JF Hultquist - Bmj, 2022 - bmj.com
Soon after the omicron SARS-CoV-2 variant of concern was first reported to the World
Health Organization on 24 November 2021, preliminary observational studies in South …

[HTML][HTML] Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections

KJ Selva, P Ramanathan, ER Haycroft, A Reynaldi… - JCI insight, 2023 - ncbi.nlm.nih.gov
Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination
is crucial to develop strategies for longer term immunity, especially against emerging viral …

Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection

WS Lee, HX Tan, A Reynaldi, R Esterbauer… - Science …, 2023 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of
vaccinated individuals is increasingly common with the circulation of highly immune evasive …

[HTML][HTML] Heterogeneous SARS-CoV-2 kinetics due to variable timing and intensity of immune responses

K Owens, S Esmaeili, JT Schiffer - JCI insight, 2024 - ncbi.nlm.nih.gov
The viral kinetics of documented SARS-CoV-2 infections exhibit a high degree of
interindividual variability. We identified 6 distinct viral shedding patterns, which differed …

Comparing the immune response and protective effect of COVID-19 vaccine under different vaccination strategies

T Zhao, X Huang, Y Shu - Human Vaccines & Immunotherapeutics, 2023 - Taylor & Francis
Although highly infectious respiratory viral infections spread rapidly, humans have evolved a
precise and complex immune mechanism to deal with respiratory viruses, with strong …

Rational design of a booster vaccine against COVID-19 based on antigenic distance

YF Hu, TTT Yuen, HR Gong, B Hu, JC Hu, XS Lin… - Cell Host & Microbe, 2023 - cell.com
Current COVID-19 vaccines are highly effective against symptomatic disease, but repeated
booster doses using vaccines based on the ancestral strain offer limited additional …