The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

T Yang, EM Richards, CJ Pepine… - Nature Reviews …, 2018 - nature.com
Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …

Diagnosis and treatment of arterial hypertension 2021

C Ott, RE Schmieder - Kidney international, 2022 - Elsevier
In the last 4 years, several evidence-based, national, and international guidelines on the
management of arterial hypertension have been published, mostly with concordant …

Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised …

RR Townsend, F Mahfoud, DE Kandzari, K Kario… - The Lancet, 2017 - thelancet.com
Background Previous randomised renal denervation studies did not show consistent efficacy
in reducing blood pressure. The objective of our study was to evaluate the effect of renal …

Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry

F Mahfoud, M Böhm, R Schmieder… - European Heart …, 2019 - academic.oup.com
Aims Several studies and registries have demonstrated sustained reductions in blood
pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in …

Sympathetic nervous system contributions to hypertension: updates and therapeutic relevance

LJ DeLalio, AF Sved, SD Stocker - Canadian Journal of Cardiology, 2020 - Elsevier
The sympathetic nervous system plays a pivotal role in the long-term regulation of arterial
blood pressure through the ability of the central nervous system to integrate neurohumoral …

Renal denervation: a review

J Rey-García, RR Townsend - American Journal of Kidney Diseases, 2022 - Elsevier
Uncontrolled hypertension persists as an important health issue despite the availability of
many medications and nondrug therapies that lower blood pressure. Increasingly …

Renal denervation in Asia: consensus statement of the Asia Renal Denervation Consortium

K Kario, BK Kim, J Aoki, AY Wong, YH Lee… - …, 2020 - Am Heart Assoc
The Asia Renal Denervation Consortium consensus conference of Asian physicians actively
performing renal denervation (RDN) was recently convened to share up-to-date information …

Sustained decrease in blood pressure and reduced anatomical and functional reinnervation of renal nerves in hypertensive sheep 30 months after catheter-based …

RR Singh, ZM McArdle, M Iudica, LK Easton… - …, 2019 - Am Heart Assoc
We examined whether renal denervation (RDN) reduced blood pressure (BP), improved
glomerular filtration rate, albuminuria, and left ventricular mass in sheep with hypertensive …

Cardiorenal syndrome and heart failure—challenges and opportunities

H Yogasundaram, MC Chappell, B Braam… - Canadian Journal of …, 2019 - Elsevier
Cardiorenal syndromes (CRS) describe concomitant bidirectional dysfunction of the heart
and kidneys in which 1 organ initiates, perpetuates, and/or accelerates decline of the other …

Clinical event reductions in high-risk patients after renal denervation projected from the global SYMPLICITY registry

RE Schmieder, F Mahfoud, G Mancia… - … Journal-Quality of …, 2023 - academic.oup.com
Aims Renal denervation has been shown to lower blood pressure in sham-controlled trials
and represents a device-based treatment option for hypertension. We sought to project …