Background Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of
the immune system and leads to the photoaging state which is reminiscent of chronological …

Aging is related to a number of functional and morphological changes leading to
progressive decline of the biological functions of an organism. Reactive Oxygen Species …

Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

In recent years, cellular senescence has generated a lot of interest among researchers
because of its involvement in both the normal aging process and common human diseases …

Cytosolic double-stranded DNA surveillance by cyclic GMP-AMP synthase (cGAS)–
Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy …

Circulating senescent CD8+ T (T8sen) cells are characterized by a lack of proliferative
capacities but retain cytotoxic activity and have been associated to resistance to …

The prevalence of age-related diseases is in an upward trend due to increased life
expectancy in humans. Age-related conditions are among the leading causes of morbidity …

Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling
molecules that poison surrounding cells, leading to various age-related diseases, including …

Senescence is a crucial player in several metabolic disorders and chronic inflammatory
diseases. Recent data prove the involvement of hepatocyte senescence in the development …