Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

S Rahman, MTV Montero, K Rowe… - Expert review of …, 2021 - Taylor & Francis
Introduction The COVID-19 pandemic has created a public health crisis, infected millions of
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …

[HTML][HTML] A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19

K Sharun, R Tiwari, MI Yatoo, S Natesan, D Megawati… - Narra J, 2022 - ncbi.nlm.nih.gov
The emergence of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected many countries throughout …

Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial

MI Lopes, LP Bonjorno, MC Giannini, NB Amaral… - RMD open, 2021 - rmdopen.bmj.com
Objective To evaluate whether the addition of colchicine to standard treatment for COVID-19
results in better outcomes. Design We present the results of a randomised, double-blinded …

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

CK Yinda, JR Port, T Bushmaker, I Offei Owusu… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic.
Several animal models have been rapidly developed that recapitulate the asymptomatic to …

[HTML][HTML] Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

D Scozzi, M Cano, L Ma, D Zhou, JH Zhu… - JCI insight, 2021 - ncbi.nlm.nih.gov
Background Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids
released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could …

Association between red blood cell distribution width and mortality and severity among patients with COVID‐19: a systematic review and meta‐analysis

JJ Lee, SM Montazerin, A Jamil, U Jamil… - Journal of medical …, 2021 - Wiley Online Library
Emerging evidence has underscored the potential usefulness of red blood cell distribution
width (RDW) measurement in predicting the mortality and disease severity of COVID‐19 …

Neurological Manifestations in COVID-19 Patients: A Meta-Analysis.

A Sharma, A Kumar, SJS Flora - ACS chemical neuroscience, 2021 - europepmc.org
Common symptoms such as dizziness, headache, olfactory dysfunction, nausea, vomiting,
etc. in COVID-19 patients have indicated the involvement of the nervous system. However …

Associations between Serum Interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐8, and IL‐10) and Disease Severity of COVID‐19: A Systematic Review and Meta‐Analysis

Y Chang, M Bai, Q You - BioMed Research International, 2022 - Wiley Online Library
Background. To investigate the association between interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐
8, and IL‐10) and the disease severity of coronavirus disease 2019 (COVID‐19). Materials …

Predictive value of systemic immune-inflammation index and neutrophil-to-lymphocyte ratio in patients with severe COVID-19

W Xia, Y Tan, S Hu, C Li… - Clinical and Applied …, 2022 - journals.sagepub.com
Objective: It was initially reported that a novel coronavirus (COVID-19) had been identified in
Wuhan, China, in December 2019. To date, COVID-19 is still threatening all humanity and …

[HTML][HTML] Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19

DM Kim, Y Kim, JW Seo, J Lee, U Park, NY Ha, J Koh… - Cell reports, 2021 - cell.com
Despite the worldwide effect of the coronavirus disease 2019 (COVID-19) pandemic, the
underlying mechanisms of fatal viral pneumonia remain elusive. Here, we show that critical …