Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

Transcription in several organisms from certain bacteria to humans has been observed to be
stochastic in nature: toggling between active and inactive states. Periods of active nascent …

Transcription factors show rapid and reversible binding to chromatin in living cells, and
transcription occurs in sporadic bursts, but how these phenomena are related is unknown …

Enzymatic probes of chromatin structure reveal accessible versus inaccessible chromatin
states, while super-resolution microscopy reveals a continuum of chromatin compaction …

The classic view of nucleosome organization at active promoters is that two well-positioned
nucleosomes flank a nucleosome-depleted region (NDR). However, this view has been …

The dynamic architecture of chromatin fibers, a key determinant of genome regulation, is
poorly understood. Here, we employ multimodal single-molecule Förster resonance energy …

Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate
DNA processes, including transcription, replication, and repair. Conformational dynamics …

Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

Gene regulation in eukaryotes requires the controlled access of sequence-specific
transcription factors (TFs) to their sites in a chromatin landscape dominated by …