Clinical neurophysiology of aging brain: from normal aging to neurodegeneration

PM Rossini, S Rossi, C Babiloni, J Polich - Progress in neurobiology, 2007 - Elsevier
Physiological brain aging is characterized by a loss of synaptic contacts and neuronal
apoptosis that provokes age-dependant decline of sensory processing, motor performance …

P300 as a clinical assay: rationale, evaluation, and findings

J Polich, KL Herbst - International Journal of Psychophysiology, 2000 - Elsevier
Use of the P300 event-related brain potential (ERP) as a clinical assay is reviewed and
assessed by comparing its distribution qualities with normative biomedical testing data from …

Clinical application of the P300 event-related brain potential

J Polich - Physical Medicine and Rehabilitation Clinics, 2004 - pmr.theclinics.com
Neuroelectric measures can provide direct imaging of central nervous system function.
Electroencephalographic (EEG) and evoked potential techniques have been used clinically …

Meta‐analysis of P300 normative aging studies

J Polich - Psychophysiology, 1996 - Wiley Online Library
The theoretical and empirical backgrounds for the utility of the P300 event‐related potential
(ERP) as a measure of cognitive aging are summarized. P300 latency data from 32 different …

Revisiting the oddball paradigm. Non-target vs neutral stimuli and the evaluation of ERP attentional effects

L García-Larrea, AC Lukaszewicz, F Mauguiére - Neuropsychologia, 1992 - Elsevier
We recorded topographic mapping of auditory evoked potentials (AEPs) to homogeneous
series of tones delivered in the absence of any cognitive task (“neutral condition”) and …

P300 clinical utility and control of variability

J Polich - Journal of Clinical Neurophysiology, 1998 - journals.lww.com
The P300 event-related brain potential (ERP) has been used to study normal aging as well
as patient populations with a variety of neurologic and psychiatric disorders. The P300 has …

P300 in clinical applications: meaning, method, and measurement

J Polich - American Journal of EEG Technology, 1991 - Taylor & Francis
The P300 (P3) event-related brain potential (ERP) is sensitive to the cognitive changes
resulting from normal aging and the mental decline associated with dementia and other …

Multichannel auditory event-related brain potentials: effects of normal aging on the scalp distribution of N1, P2, N2 and P300 latencies and amplitudes

P Anderer, HV Semlitsch, B Saletu - Electroencephalography and clinical …, 1996 - Elsevier
Event-related potentials (ERPs) were recorded at 17 leads in an auditory oddball paradigm
in 172 normal healthy subjects aged between 20 and 88 years. With advancing age, N1 …

P300, stimulus intensity, modality, and probability

J Polich, PC Ellerson, J Cohen - International Journal of Psychophysiology, 1996 - Elsevier
Auditory and visual stimulus intensity were manipulated factorially with target probability to
assess the influence of these variables on the P300 component of the event-related brain …

Cognitive performance, mood and experimental pain before and during morphine-induced analgesia in patients with chronic non-malignant pain

J Lorenz, H Beck, B Bromm - Pain, 1997 - Elsevier
This paper investigates subjective, behavioral and neurophysiological changes due to
treatment with oral sustained-release morphine in six patients with severe non-malignant …