Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is
governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways …

Severe pain is often experienced by patients with head and neck cancer and is associated
with a poor prognosis. Despite its frequency and severity, current treatments fail to …

Simple Summary Cisplatin is a chemotherapy drug extensively used to treat cancer,
improving the survival of cancer patients. Although effective for this purpose, its use is …

Nephrotoxicity is a major side effect of cisplatin treatment of solid tumors in the clinical
setting. Long-term low-dose cisplatin administration causes renal fibrosis and inflammation …

Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently
associated with cisplatin use. Although its pathophysiology is poorly understood, it is known …

Chemotherapy has a significant positive impact in cancer treatment outcomes, reducing
recurrence and mortality. However, many cancer surviving children and adults suffer from …

Although their efficacy has been well-established in Oncology, the use of platinum salts
remains limited due to the occurrence of acute kidney injury (AKI). Caffeine has been …

Neuropathy is a terrible disorder that has a wide range of etiologies. Drug-induced
neuropathy, which happens whenever a chemical agent damages the peripheral nerve …

肾脏间质纤维化是许多肾脏疾病不断进展的共同路径. 不管是各种慢性肾脏病,
或是各种因素所引起的无法完全恢复的急性肾损伤, 其进展过程多数是在经过肾脏间质纤维化后 …

Chemotherapy-induced toxicities, such as neuropathy, are accepted consequences of some
effective therapies. However, neuropathy is also a primary dose-limiting complication of …