Signaling inflammation across the gut-brain axis

G Agirman, KB Yu, EY Hsiao - Science, 2021 - science.org
The brain and gastrointestinal tract are critical sensory organs responsible for detecting,
relaying, integrating, and responding to signals derived from the internal and external …

[HTML][HTML] Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications

YT Fang, YT Lin, WL Tseng, P Tseng… - Frontiers in Aging …, 2023 - frontiersin.org
Vagus nerve stimulation (VNS) is a technology that provides electrical stimulation to the
cervical vagus nerve and can be applied in the treatment of a wide variety of …

[HTML][HTML] Transcutaneous auricular vagus nerve stimulation attenuates inflammatory bowel disease in children: a proof-of-concept clinical trial

B Sahn, K Pascuma, N Kohn, KJ Tracey… - Bioelectronic …, 2023 - Springer
Background Vagus nerve stimulation is an investigational anti-inflammatory therapy
targeting the nervous system to modulate immune activity. This study evaluated the efficacy …

[HTML][HTML] Role of vagus nerve stimulation in the treatment of chronic pain

P Shao, H Li, J Jiang, Y Guan, X Chen… - …, 2023 - karger.com
Vagus nerve stimulation (VNS) can modulate vagal activity and neuro-immune
communication. Human and animal studies have provided growing evidence that VNS can …

Anti‐neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression‐like behaviors via hypothalamic α7nAchR/JAK2/STAT3/NF‐κB …

Y Chen, Y Zhang, J Wang, S Li, Y Wang… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a vital
neuromodulation for the treatment of depression, but its antidepressant molecular …

[HTML][HTML] Transcutaneous electrical acustimulation improves irritable bowel syndrome with constipation by accelerating colon transit and reducing rectal sensation …

Z Huang, Z Lin, C Lin, H Chu, X Zheng… - Official journal of the …, 2022 - journals.lww.com
METHODS: Fifty-two patients with IBS-C were randomized into 2 groups: daily TEA for 4
weeks (n= 26) and daily sham-TEA for 4 weeks (n= 26). The number of complete …

[HTML][HTML] Are neuromodulation interventions associated with changes in the gut microbiota? A systematic review

V Korenblik, ME Brouwer, A Korosi, D Denys… - …, 2023 - Elsevier
The microbiota-gut-brain axis (MGBA) refers to the bidirectional communication between the
brain and the gut microbiota and recent studies have linked the MGBA to health and …

Update on treatment of abdominal pain in irritable bowel syndrome: A narrative review

M Camilleri, S Dilmaghani - Pharmacology & Therapeutics, 2023 - Elsevier
The objectives of this narrative review are to update readers on the current state-of-the-art
regarding diverse approaches for the treatment of pain, global symptoms, or adequate relief …

[HTML][HTML] Ameliorating effects of transcutaneous auricular vagus nerve stimulation on a mouse model of constipation-predominant irritable bowel syndrome

J Liu, Q Dai, T Qu, J Ma, C Lv, H Wang, Y Yu - Neurobiology of Disease, 2024 - Elsevier
Limited treatment options have been shown to alter the natural course of constipation-
predominant irritable bowel syndrome (IBS-C). Therefore, safer and more effective …

[HTML][HTML] Auricular vagus nerve stimulation improves visceral hypersensitivity and gastric motility and depression-like behaviors via vago-vagal pathway in a rat model …

L Hou, P Rong, Y Yang, J Fang, J Wang, Y Wang… - Brain Sciences, 2023 - mdpi.com
Transcutaneous auricular vagus nerve stimulation was recently reported to have a
therapeutic potential for functional dyspepsia (FD). This study aimed to explore the …