[HTML][HTML] Hallmarks of aging: An expanding universe
Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Regulatory activity is the default DNA state in eukaryotes
I Luthra, C Jensen, XE Chen, AL Salaudeen… - Nature Structural & …, 2024 - nature.com
Genomes encode for genes and non-coding DNA, both capable of transcriptional activity.
However, unlike canonical genes, many transcripts from non-coding DNA have limited …
However, unlike canonical genes, many transcripts from non-coding DNA have limited …
Structure-guided isoform identification for the human transcriptome
Recently developed methods to predict three-dimensional protein structure with high
accuracy have opened new avenues for genome and proteome research. We explore a new …
accuracy have opened new avenues for genome and proteome research. We explore a new …
[HTML][HTML] CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein …
CHESS 3 represents an improved human gene catalog based on nearly 10,000 RNA-seq
experiments across 54 body sites. It significantly improves current genome annotation by …
experiments across 54 body sites. It significantly improves current genome annotation by …
Protection of the human gene research literature from contract cheating organizations known as research paper mills
JA Byrne, Y Park, RAK Richardson… - Nucleic Acids …, 2022 - academic.oup.com
Human gene research generates new biology insights with translational potential, yet few
studies have considered the health of the human gene literature. The accessibility of human …
studies have considered the health of the human gene literature. The accessibility of human …
Molecular mechanism of lncRNAs in pathogenesis and diagnosis of auto-immune diseases, with a special focus on lncRNA-based therapeutic approaches
Autoimmune diseases are a diverse set of conditions defined by organ damage due to
abnormal innate and acquired immune system responses. The pathophysiology of …
abnormal innate and acquired immune system responses. The pathophysiology of …
Selection on synonymous sites: the unwanted transcript hypothesis
Although translational selection to favour codons that match the most abundant tRNAs is not
readily observed in humans, there is nonetheless selection in humans on synonymous …
readily observed in humans, there is nonetheless selection in humans on synonymous …
[HTML][HTML] The p-arms of human acrocentric chromosomes play by a different set of rules
B McStay - Annual Review of Genomics and Human Genetics, 2023 - annualreviews.org
The p-arms of the five human acrocentric chromosomes bear nucleolar organizer regions
(NORs) comprising ribosomal gene (rDNA) repeats that are organized in a homogeneous …
(NORs) comprising ribosomal gene (rDNA) repeats that are organized in a homogeneous …
mRNA nuclear export: how mRNA identity features distinguish functional RNAs from junk transcripts
AF Palazzo, Y Qiu, YM Kang - RNA biology, 2024 - Taylor & Francis
The division of the cellular space into nucleoplasm and cytoplasm promotes quality control
mechanisms that prevent misprocessed mRNAs and junk RNAs from gaining access to the …
mechanisms that prevent misprocessed mRNAs and junk RNAs from gaining access to the …