Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …

Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to …

Background The effectiveness of the COVID-19 vaccination programme depends on mass
participation: the greater the number of people vaccinated, the less risk to the population …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

The British Association for Psychopharmacology developed an evidence-based consensus
guideline on the management of catatonia. A group of international experts from a wide …

Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

Chronic pain, as a stress state, is one of the critical factors for determining depression, and
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …

Background The degree of efficacy, safety, quality, and certainty of meta-analytic evidence of
biological non-pharmacological treatments in mental disorders is unclear. Methods We …

The serotonergic system forms a diffuse network within the central nervous system and plays
a significant role in the regulation of mood and cognition. Manipulation of tryptophan levels …