One of the key features of cancer is metabolic reprogramming that can be exploited to
sensitize cancer cells to chemotherapy. Trimetazidine (TMZ) is a metabolic anti-ischemic …

To compare the effects of aminosalicylic acid, glucocorticoids and immunosuppressants on
the expression levels of multidrug resistance genes in patients with ulcerative colitis (UC) …

ATC is a very rare, but extremely aggressive form of thyroid malignancy, responsible for the
highest mortality rate registered for thyroid cancer. In patients without known genetic …

Drug resistance is a major impediment to patient survival and remains the primary cause of
unsuccessful cancer therapy. Drug resistance occurs in many tumors and is frequently …

The contribution of autophagy to drug resistance has been studied in several cancers.
However, there is no clear evidence about the role of autophagy in the resistance to …

The P-glycoprotein (P-gp) plays a major role in the efflux of chemotherapeutic drugs and
significantly limits chemotherapy efficacy. Chemosensitizers augment the therapeutic effects …

Simple Summary Doxorubicin (DOX) is widely used in the treatment of breast cancer.
However, resistance limits its effectiveness. In particular, breast cancer stem cells (BCSCs) …

Breast cancer is the most common type of cancer and is the second leading cause of cancer-
related mortality in women. Chemotherapy, targeted therapy, endocrine therapy, and …

This study aimed to investigate the protective effects of S-adenosylmethionine (SAM) on
irinotecan-induced intestinal barrier dysfunction and microbial ecological dysregulation in …

Naphthylisoquinoline (NIQ) alkaloids are rising as a promising class of secondary
metabolites with pharmaceutical potential. NF-κB has already been recognized as a …