Scopolamine is a nonselective muscarinic antagonist that has shown relatively rapid
antidepressant effects, although to date the results are from limited clinical studies …

Rationale Clinical reports reveal that scopolamine, an acetylcholine muscarinic receptor
antagonist, exerts rapid antidepressant effects in depressed patients, but the mechanisms …

The molecular and cellular mechanisms underlying the pathogenesis of depression remain
unclear. Over the past two decades, studies have highlighted a potential role for …

Verapamil is a phenylalkylamine class calcium channel blocker that for half a century has
been used for the treatment of cardiovascular diseases. Nowadays, verapamil is also …

Magnetic brain stimulation has greatly contributed to the advancement of neuroscience.
However, challenges remain in the power of penetration and precision of magnetic …

In contrast with the delayed onset of therapeutic responses and relatively low efficacy of
currently available monoamine-based antidepressants, a single subanesthetic dose of …

The dose-dependent effects of alcohol, where the initial euphoric and stimulant effects
initiated by the exposure to low ethanol levels can quickly lead to a deadly consequence are …

Iron supplementation previously demonstrated antidepressant-like effects in post-partum
rats. The present study evaluates the possible synergistic antidepressant effect of sub …

Background Major depressive disorder (MDD) is the leading cause of disability around the
world. It is generally agreed that the central cholinergic system plays an important role in …

Anisodus tanguticus (Maxim.) Pascher, a medicinal plant growing in the Tibetan Plateau
region with various medicinal values, is mainly used for the extraction of tropane alkaloids …