Conventional antidepressants typically require weeks of daily dosing to achieve full
antidepressant response in antidepressant responders. A newly evolving group of …

For a depressed patient, a single day without symptom improvement means yet another day
of suffering. The currently available antidepressants require weeks or months to achieve …

Long-term spaceflight has always been challenging for astronauts due to the extremely
complicated space environmental conditions, including microgravity, noise, confinement …

Background: Major depressive disorder (MDD) is a prevalent neuropsychiatric disease that
carries a staggering global burden. Although numerous antidepressants are available on …

Background Metformin is the most widely used drug for treating type 2 diabetes mellitus
(DM), which frequently co-occurs with depressive disorders. Thus, patients with depression …

Bicaudal C homolog 1 gene (BICC1) in the medial prefrontal cortex (mPFC) has been
implicated in major depressive disorder (MDD); however, less is known about the …

Background: Scopolamine, a non-selective muscarinic acetylcholine receptor (M1~ 5-AChR)
antagonist, has rapid and robust antidepressant effects in humans and other species …

The first antidepressants, discovered in the 1950s, and any successors directly target the
monoaminergic brain systems. Problems in this group, however, are low effectiveness (only …

Тропановые алкалоиды (ТА) являются метаболитами различных видов растений
семейств Brassicaceae, Solanaceae и Erythroxylaceae. Семена этих сорных растений …

The nonselective muscarinic antagonist scopolamine is a rapid-acting antidepressant in
limited clinical studies and shares common downstream signaling partners to ketamine …