Highlights•Adjuvants potentiate existing antibiotics or combat mechanisms of
resistance.•Probes enable the identification of enzymes that modify tuberculosis …

Background Cefiderocol and ceftazidime-avibactam plus aztreonam (CZA-ATM) are
preferred treatment regimens for New Delhi metallo-β-lactamase (NDM)-producing …

Background Antibiotic resistance has become a public health problem to be solved
worldwide and metallo-β-lactamase (MBL)-producing bacteria make this problem even more …

Carbapenem-resistant Enterobacterales (CRE) has emerged as a worldwide spread
nosocomial superbug exhibiting antimicrobial resistance (AMR) to all current antibiotics …

Cefiderocol (CFDC) is the first-in-class siderophore-cephalosporin. Klebsiella pneumoniae
strain that is extremely resistant to CFDC (MIC: 256 µg/ml) was isolated for the first time in …

ABSTRACT Metallo-β-lactamases (MBLs) represent one of the main causes of carbapenem
resistance in the order Enterobacterales. To combat MBL-producing carbapenem-resistant …

β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding
proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis. A …

Antimicrobial resistance is a great public health concern that is now described as a “silent
pandemic”. The global burden of antimicrobial resistance requires new antibacterial …

Metallo beta lactamases (MBLs) are among the most problematic resistance mechanisms of
multidrug-resistant Gram-negative pathogens due to their broad substrate spectrum and lack …

Abstract Metallo-β-lactamases (MBLs) are a class of enzymes that are produced by a variety
of bacterial species and are responsible for conferring resistance to a broad range of β …