Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell,
such as metabolism, DNA synthesis, movement and information processing. These …

Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most
crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin …

Computational modeling and the theory of nonlinear dynamical systems allow one to not
simply describe the events of the cell cycle, but also to understand why these events occur …

The restriction point (R-point) marks the critical event when a mammalian cell commits to
proliferation and becomes independent of growth stimulation. It is fundamental for normal …

The transcription factors E2F and Myc participate in the control of cell proliferation and
apoptosis, and can act as oncogenes or tumor suppressors depending on their levels of …

Cellular quiescence is a reversible non-proliferating state. The reactivation of 'sleep-
like'quiescent cells (eg fibroblasts, lymphocytes and stem cells) into proliferation is crucial for …

The capacity for multiple equilibria in an isothermal homogeneous continuous flow stirred
tank reactor is determined by the reaction network. Examples show that there is a very …

We propose an integrated computational model for the network of cyclin-dependent kinases
(Cdks) that controls the dynamics of the mammalian cell cycle. The model contains four Cdk …

We propose a protein interaction network for the regulation of DNA synthesis and mitosis
that emphasizes the universality of the regulatory system among eukaryotic cells. The …

Epidermal growth factor (EGF) receptors (EGFRs) and signaling pathways activated by
these receptors have been associated with development of breast cancer as well as its …