Targeting tumor-associated angiogenesis is currently at the forefront of renal cell carcinoma
(RCC) therapy, with sunitinib and bevacizumab leading to increased survival in patients with …

Introduction Cancer mortality worldwide highlights the urgency for advanced therapeutic
methods to fill the gaps in conventional cancer therapies. Bacteriotherapy is showing great …

Simple Summary Pancreatic cancer, including primarily pancreatic ductal adenocarcinoma
(PDAC), represents a highly lethal disease and an increasingly common cause of cancer …

Almost every aspect of cancer can be influenced by microbiota including tumor onset,
progression, and response to therapy. The increasing evidence of the role of microbiota in …

Cancer therapies, such as chemotherapy and radiotherapy, are often unsatisfactory due to
several limitations, including drug resistance, inability to cross biological barriers, and toxic …

合成生物学有望创造具备独特优势的抗肿瘤微生物疫苗, 合成生物学改造的微生物更能适应肿瘤
微环境并在其中富集与增殖, 削弱或者逆转免疫抑制细胞的功能, 并增强肿瘤抗原的呈递 …

The combination of precise tumor depletion and immunotherapy presents great potential to
exterminate cancer disease. Anaerobic bacteria can trigger innate and adaptive immune …

The gut microbiota produce specialized metabolites that are important for maintaining host
health homeostasis. Hence, unstable production of these metabolites can contribute to …

The major reason for the failure of conventional therapies is the heterogeneity and
complexity of tumor microenvironments (TMEs). Many malignant tumors reprogram their …

Although immunotherapy has revolutionized cancer treatment and achieved remarkable
success across many different cancer types, only a subset of patients shows meaningful …