Background CD4+ T cells are key contributors to cancer immune surveillance. However,
means to effectively harness CD4+ T cell help for cancer immunotherapy are lacking, and …

Pancreatic cancer remains the most malignant type of cancer. Although immunotherapy has
shown good efficacy in most solid tumors, it has a poor response in pancreatic cancer. The …

Bacteria can be engineered to effectively deliver therapeutics in specific tissues, including
tumours. Two articles have now described different approaches to improve the design and …

Pancreatic cancer (PC) has an unfavorable prognosis with few effective therapeutic options.
This has led researchers to investigate the possible links between microbiota and PC. A …

Among bacteria used as anticancer vaccines, attenuated Listeria monocytogenes (Lmat)
stands out because it spreads from one infected cancer cell to the next, induces a strong …

Using toxin-producing bacteria to treat explants and autochthonous mouse models of
pancreatic cancer Amanda R. Decker Submitted Page 1 Using toxin-producing bacteria to …

Prostate cancer (PCa) has the second highest incidence of all malignancies in men
worldwide. Advanced PCa shows overwhelming de novo resistance to immunotherapy …

Pancreatic cancer is the sixth leading cause of cancer-related death in China. It is
characterized by high malignancy and concealment at early stages. More than 80% of …

Cancer is the leading cause of death in Canada. Current treatments, such as chemotherapy
and radiation, have high rates of adverse effects leading to dose-limiting toxicities and …

Engineered therapeutic bacteria for the treatment of oral squamous cell carcinoma Engineered
therapeutic bacteria for the treatment of oral squamous cell carcinoma Oral Oncol. 2022 …