Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

Annexin A2 is a pleiotropic calcium-and anionic phospholipid-binding protein that exists as
a monomer and as a heterotetrameric complex with the plasminogen receptor protein …

Abstract Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …

Antiphospholipid Syndrome (APS) is characterized by vascular thrombosis and/or
pregnancy morbidity occurring in patients with persistent antiphospholipid antibodies (aPL) …

Factor H (FH) is an abundant regulator of complement activation and protects host cells from
self-attack by complement. Here we provide insight into the regulatory activity of FH by …

Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids
with well-recognized structural roles in cellular membranes. They are also signaling lipids …

The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies in
blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I …

Summary β 2‐Glycoprotein I (β 2‐GPI) is a protein that circulates in blood at high
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …

The high affinity of human plasma β2‐glycoprotein I (β 2 GPI), also known as apolipoprotein‐
H (ApoH), for negatively charged phospholipids determines its implication in a variety of …