Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …

In December 2019, the outbreak of the novel coronavirus disease (COVID-19) in China
spread worldwide, becoming an emergency of major international concern. SARS-CoV-2 …

Ever since the development of the first vaccine more than 200 years ago, vaccinations have
greatly decreased the burden of infectious diseases worldwide, famously leading to the …

Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Background rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-
based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested …

Since its outbreak in late 2019, the novel coronavirus disease 2019 (COVID-19) has spread
to every continent on the planet. The global pandemic has affected human health and …

Background A recombinant, replication-competent vesicular stomatitis virus-based vaccine
expressing a surface glycoprotein of Zaire Ebolavirus (rVSV-ZEBOV) is a promising Ebola …

Ebolaviruses are pathogenic agents associated with a severe, potentially fatal, systemic
disease in man and great apes. Four species of ebolaviruses have been identified in west or …

Background The worst Ebola virus disease (EVD) outbreak in history has resulted in more
than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an …

Background The safety and efficacy of vaccines to prevent Ebola virus disease (EVD) were
unknown when the incidence of EVD was peaking in Liberia. Methods We initiated a …