Cellular metabolism: A fundamental component of degeneration in the nervous system

K Maiese - Biomolecules, 2023 - mdpi.com
It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

[HTML][HTML] SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway

RS Hamad, HM Al-Kuraishy, A Alexiou… - Cell Stress and …, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel
severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and …

Cognitive impairment in multiple sclerosis

K Maiese - Bioengineering, 2023 - mdpi.com
Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

[HTML][HTML] The metabolic basis for nervous system dysfunction in alzheimer's disease, parkinson's disease, and huntington's disease

K Maiese - Current neurovascular research, 2023 - ncbi.nlm.nih.gov
Disorders of metabolism affect multiple systems throughout the body, but may have the
greatest impact on both central and peripheral nervous systems. Current available …

The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

Receptor-dependent effects of sphingosine-1-phosphate (S1P) in COVID-19: the black side of the moon

HM Al-Kuraishy, GES Batiha, AI Al-Gareeb… - Molecular and Cellular …, 2023 - Springer
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection leads to
hyper-inflammation and amplified immune response in severe cases that may progress to …

Potential role of tirzepatide towards Covid-19 infection in diabetic patients: a perspective approach

GES Batiha, HM Al-Kuraishy, AI Al-Gareeb… - …, 2023 - Springer
In Covid-19, variations in fasting blood glucose are considered a distinct risk element for a
bad prognosis and outcome in Covid-19 patients. Tirazepatide (TZT), a dual glucagon-like …

Causal influences of osteoarthritis on COVID-19: a Mendelian randomization study

L Fu, A Baranova, H Cao, F Zhang - Frontiers in Medicine, 2023 - frontiersin.org
Objective Although observational and genetic studies have indicated a correlation between
OA and COVID-19, it remains uncertain whether osteoarthritis (OA) contributes to the …

Mixed storm in SARS‐CoV‐2 infection: a narrative review and new term in the Covid‐19 era

BM Alomair, HM Al‐Kuraishy… - Immunity …, 2023 - Wiley Online Library
Abstract Coronavirus disease 2019 (Covid‐19) is caused by a novel severe acute
respiratory syndrome coronavirus virus type 2 (SARS‐CoV‐2) leading to the global …

Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden

L Alkazmi, HM Al‐kuraishy… - Clinical and …, 2023 - Wiley Online Library
Dantrolene (DTN) is a ryanodine receptor (RyR) antagonist that inhibits Ca2+ release from
stores in the sarcoplasmic reticulum. DTN is mainly used in the management of malignant …