Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …

Breakthroughs in the development of high-throughput technologies for profiling
transcriptomes at the single-cell level have helped biologists to understand the …

Erythropoietin (Epo) is the master regulator of erythropoiesis and oxygen homeostasis.
Despite its physiological importance, the molecular and genomic contexts of the cells …

Background Single-cell RNA sequencing has been widely adopted to estimate the cellular
composition of heterogeneous tissues and obtain transcriptional profiles of individual cells …

Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …

Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …

Background Current management of AKI, a potentially fatal disorder that can also initiate or
exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular …

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a nonapoptotic
form of regulated cell death that has been implicated in maladaptive renal repair in mice and …

During development, distinct progenitors contribute to the nephrons versus the ureteric
epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of …

Background The roles of asymptomatic hyperuricemia or uric acid (UA) crystals in CKD
progression are unknown. Hypotheses to explain links between UA deposition and …