The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

The LDLR family of proteins is involved in lipoproteins trafficking. While the role of LDLR in
cardiovascular disease has been widely studied, only recently the role of other members of …

Scavenger receptors constitute a large family of proteins that are structurally diverse and
participate in a wide range of biological functions. These receptors are expressed …

Obesity-related leptin resistance manifests in loss of leptin's ability to reduce appetite and
increase energy expenditure. Obesity is also associated with increased activity of the …

Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its
possible roles in obesity development and in adipocyte metabolism are unclear. The …

Since the discovery of the low-density lipoprotein receptor (LDLR) and its association with
familial hypercholesterolemia in the early 1980s, a family of structurally related proteins has …

Abstract Lipocalin-2 (LCN2) is an acute phase protein with multiple functions that has
garnered a great deal of interest over the last decade. However, its precise role in the …

Inflammation plays a critical role in the development of severe neonatal morbidities. Myeloid-
derived suppressor cells (MDSCs) were recently implicated in the regulation of immune …

Lipocalin-2 (LCN2) is an inflammatory mediator best known for its role as an innate acute-
phase protein. LCN2 mediates the innate immune response to pathogens by sequestering …

Receptor-mediated endocytosis in renal proximal tubule epithelial cells (PTECs) is important
for the reabsorption and metabolization of proteins and other substances, including carrier …