Hyperuricemia and endothelial function: is it a simple association or do gender differences play a role in this binomial?
T Ciarambino, P Crispino, M Giordano - Biomedicines, 2022 - mdpi.com
The endothelium plays a fundamental role in the biological processes that ensure
physiological vessel integrity, synthesizing numerous substances that are capable of …
physiological vessel integrity, synthesizing numerous substances that are capable of …
Zinc finger proteins and ATP‐binding cassette transporter‐dependent multidrug resistance
S Barzegar, S Pirouzpanah - European Journal of Clinical …, 2024 - Wiley Online Library
Background Multidrug resistance (MDR) remains a significant challenge in cancer treatment,
leading to poor clinical outcomes. Dysregulation of ATP‐binding cassette (ABC) transporters …
leading to poor clinical outcomes. Dysregulation of ATP‐binding cassette (ABC) transporters …
The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells
Introduction: The overexpression of ATP-binding cassette (ABC) transporters, ABCB1 and
ABCG2, are two of the major mediators of multidrug resistance (MDR) in cancers. Although …
ABCG2, are two of the major mediators of multidrug resistance (MDR) in cancers. Although …
Quinoa (Chenopodium quinoa Willd) Bran Saponins Alleviate Hyperuricemia and Inhibit Renal Injury by Regulating the PI3K/AKT/NFκB Signaling Pathway and Uric …
X Lin, Q Zhou, L Zhou, Y Sun, X Han… - Journal of Agricultural …, 2023 - ACS Publications
Triterpenoids derived from natural products can exert antihyperuricemic effects. Here, we
investigated the antihyperuricemic activity and mechanism of quinoa bran saponins (QBSs) …
investigated the antihyperuricemic activity and mechanism of quinoa bran saponins (QBSs) …
Mining Xanthine Oxidase Inhibitors from an Edible Seaweed Pterocladiella capillacea by Using In Vitro Bioassays, Affinity Ultrafiltration LC-MS/MS, Metabolomics …
Y Wang, L Zhou, M Chen, Y Liu, Y Yang, T Lu, F Ban… - Marine Drugs, 2023 - mdpi.com
The prevalence of gout and the adverse effects of current synthetic anti-gout drugs call for
new natural and effective xanthine oxidase (XOD) inhibitors to target this disease. Based on …
new natural and effective xanthine oxidase (XOD) inhibitors to target this disease. Based on …
The frequency of rs2231142 in ABCG2 among Asian subgroups: implications for personalized rosuvastatin dosing
K Alrajeh, YM Roman - Pharmacogenomics, 2023 - Taylor & Francis
Statins are widely used medications for the primary and secondary prevention of
cardiovascular diseases. Statin-induced musculoskeletal symptoms are the primary adverse …
cardiovascular diseases. Statin-induced musculoskeletal symptoms are the primary adverse …
Two important anticancer mechanisms of natural and synthetic chalcones
T Constantinescu, AG Mihis - International Journal of Molecular Sciences, 2022 - mdpi.com
ATP-binding cassette subfamily G and tubulin pharmacological mechanisms decrease the
effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin …
effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin …
[HTML][HTML] Effect of Eucommia ulmoides leaves on hyperuricemia and kidney injury induced by a high-fat/high-fructose diet in rats
M Gong, H Zhang, X Liu, Q Li, Y Zhang… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Objective (s): To investigate the protective and preventive treatment effects of Eucommia
ulmoides leaves on a rat model of high-fat and high-fructose diet (HFFD) induced …
ulmoides leaves on a rat model of high-fat and high-fructose diet (HFFD) induced …
Pro-Inflammatory Diets Promote the Formation of Hyperuricemia
X Liu, TY Chen, TY Gao, KQ Shi, FQ Yin… - Frontiers in …, 2024 - frontiersin.org
Background: Hyperuricemia, as a very prevalent chronic metabolic disease with increasing
prevalence year by year, poses a significant burden on individual patients as well as on the …
prevalence year by year, poses a significant burden on individual patients as well as on the …
Purification, characterization and anti-hyperuricemic mechanism of novel xanthine oxidase inhibitory peptides from tea (Camellia sinensis L.) protein
F Ma, S Sun, H Ye, Z Zhang, Q Chen, S Yin, Y Cao… - Food Bioscience, 2024 - Elsevier
In this study, two novel xanthine oxidase inhibitory peptides, PDEAVAYG (820.3602 Da) and
IAAGLQNTG (843.4450 Da), were purified and identified from tea protein hydrolysate, and …
IAAGLQNTG (843.4450 Da), were purified and identified from tea protein hydrolysate, and …