The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Uromodulin (or Tamm-Horsfall protein) is a glycoprotein uniquely produced in the kidney by
tubular cells of the thick ascending limb of the loop of Henle and early distal tubules. This …

Corin, a transmembrane serine protease that can cleave pro‐atrial natriuretic peptide (Pro‐
ANP) into smaller bioactive molecule atrial natriuretic peptide, has been shown to be …

Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and
animals, characterized by an increase in blood pressure (BP) following salt loading or a …

Uromodulin (UMOD) is the most abundant renal protein secreted into urine by the thick
ascending limb (TAL) epithelial cells of the loop of Henle. Genetic studies have …

Uromodulin: more than a marker for chronic kidney disease pr... : Current Opinion in Nephrology
and Hypertension Uromodulin: more than a marker for chronic kidney disease progression …

Objective: Renalase, a novel secretory flavoprotein with amine oxidase activity, is secreted
into the blood by the kidneys and is hypothesized to participate in blood pressure (BP) …

Genetic variants in UMOD associate with kidney function and hypertension. These
phenotypes are also linked to sex-related differences and impairment in cognitive and …

Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a
member of the G‐protein coupled receptor superfamily, encoded by the CHRM3 gene, in …

Neural precursor cell expressed developmentally downregulated 4‐like (NEDD4L), a
member of the E3 ubiquitin‐protein ligases, encoded by NEDD4L gene, was found to be …