Background: Despite positive preclinical studies and two positive Phase II clinical trials, two
large Phase III clinical trials of progesterone treatment of acute traumatic brain injury (TBI) …

Despite substantial investments by government, philanthropic, and commercial sources over
the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a …

The sex hormone progesterone has been shown to improve outcomes in animal models of a
number of neurologic diseases, including traumatic brain injury, ischemia, spinal cord injury …

Traumatic brain injury (TBI) can be a devastating and debilitating disease to endure. Due to
improvements in clinical practice, declining mortality rates have led to research into the long …

Independent of the cause and location, inflammation-even when minimal-has clear effects
on gastrointestinal morphology and function. These result in altered digestion, absorption …

Importance of the field: Traumatic brain injury (TBI) has yet to find a safe and effective acute-
stage neuroprotective treatment. Experimental drugs targeting a single receptor mechanism …

Aim: To explore the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in traumatic brain
injury (TBI)-induced intestinal inflammatory response and gut barrier dysfunction in the mice …

Background Traumatic brain injury (TBI) causes acute inflammatory responses that result in
an enduring cascade of secondary neuronal loss and behavioral impairments. It has been …

The intestinal mucosa is the major site of contact with antigens, and it houses the largest
lymphoid tissue in the body. In physiological conditions, microbiota and dietary antigens are …

Traumatic brain injury (TBI) is a major public-health problem for which mild TBI (MTBI)
makes up majority of the cases. MTBI is a poorly-understood health problem and can persist …