TK Choueiri, WG Kaelin Jr - Nature medicine, 2020 - nature.com
Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as …
GK Abou-Alfa, T Meyer, AL Cheng… - … England Journal of …, 2018 - Mass Medical Soc
Background Cabozantinib inhibits tyrosine kinases, including vascular endothelial growth factor receptors 1, 2, and 3, MET, and AXL, which are implicated in the progression of …
M Huang, Y Lin, C Wang, L Deng, M Chen… - Drug resistance …, 2022 - Elsevier
Angiogenesis is a hallmark of cancer and is required for tumor growth and progression. Antiangiogenic therapy has been revolutionarily developing and was approved for the …
Renal cell carcinoma (RCC) denotes cancer originated from the renal epithelium and accounts for> 90% of cancers in the kidney. The disease encompasses> 10 histological and …
PC Barata, BI Rini - CA: a cancer journal for clinicians, 2017 - researchgate.net
Over the past 12 years, medical treatment for renal cell carcinoma (RCC) has transitioned from a nonspecific immune approach (in the cytokine era), to targeted therapy against …
TK Choueiri, RJ Motzer - New England Journal of Medicine, 2017 - Mass Medical Soc
Kidney cancers have been extensively studied, and insights from an increased understanding of tumor biology have led to increases in survival rates. Therapies aimed at …
TK Choueiri, S Halabi, BL Sanford, O Hahn… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Cabozantinib is an oral potent inhibitor of vascular endothelial growth factor receptor 2, MET, and AXL and is a standard second-line therapy for metastatic renal cell …
TK Choueiri, B Escudier, T Powles, NM Tannir… - The lancet …, 2016 - thelancet.com
Background Cabozantinib is an oral inhibitor of tyrosine kinases including MET, VEGFR, and AXL. The randomised phase 3 METEOR trial compared the efficacy and safety of …