Drug response prediction in cancer cell lines is of great significance in personalized
medicine. In this study, we propose GADRP, a cancer drug response prediction model …

Novel pyridine-thiazole hybrid molecules were synthesized and subjected to physico-
chemical characterization and screening of their cytotoxic action towards a panel of cell lines …

In the era of precision medicine, radiation medicine is currently focused on the precise
delivery of highly conformal radiation treatments. However, the tremendous developments in …

DNA damage response inhibitors are widely used anti-cancer agents that have potent
activity against tumor cells with deficiencies in various DNA damage response proteins such …

DNA repair targeted therapeutics is a promising precision medicine strategy in cancer. The
development and clinical use of PARP inhibitors has transformed lives for many patients …

Introduction Prognosis of patients with metastatic pancreatic ductal adenocarcinoma
(mPDAC) remains disappointing with a 5-year overall survival of only 3–5%. Compared to …

Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in
inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol …

Motivation Synthetic lethality (SL) is a form of genetic interaction that can selectively kill
cancer cells without damaging normal cells. Exploiting this mechanism is gaining popularity …

Synthetic lethality (SL) occurs when the inactivation of two genes results in cell death while
the inactivation of either gene alone is non-lethal. SL-based therapy has become a …

Adavosertib (ADA) is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated
gallbladder cancer (GBC). However, drug resistance due to DNA damage response …