The immune response to COVID‐19: Does sex matter?
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has created unprecedented
challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …
challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …
The physiological mechanisms of the sex-based difference in outcomes of COVID19 infection
S Wray, S Arrowsmith - Frontiers in Physiology, 2021 - frontiersin.org
The scale of the SARS-CoV-2 pandemic has thrust a spotlight on the sex-based differences
in response to viral diseases; morbidity and mortality are greater in men than women. We …
in response to viral diseases; morbidity and mortality are greater in men than women. We …
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone
S Su, D Hua, JP Li, XN Zhang, L Bai, LB Cao… - … and Targeted Therapy, 2022 - nature.com
Whether and how innate antiviral response is regulated by humoral metabolism remains
enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary …
enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary …
Low testosterone levels and high estradiol to testosterone ratio are associated with hyperinflammatory state and mortality in hospitalized men with COVID-19
M Infante, M Pieri, S Lupisella, L D'Amore… - European review for …, 2021 - art.torvergata.it
Evidence supports a sex disparity in clinical outcomes of COVID-19 patients, with men
exhibiting higher mortality rates compared to women. We aimed to test the correlation …
exhibiting higher mortality rates compared to women. We aimed to test the correlation …
Progesterone aggravates lung fibrosis in a mouse model of systemic sclerosis
F Vafashoar, K Mousavizadeh, H Poormoghim… - Frontiers in …, 2021 - frontiersin.org
Background Gender-related factors have explained the higher prevalence of autoimmune
diseases in women. Sex hormones play a key role in the immune system and parenchymal …
diseases in women. Sex hormones play a key role in the immune system and parenchymal …
Assessing sex differential in COVID-19 mortality rate by age and polymerase chain reaction test results: an Iranian multi-center study
M Azizmohammad Looha… - Expert review of anti …, 2022 - Taylor & Francis
Background The aim of this study is to evaluate the sex differential effect in the COVID-19
mortality by different age groups and polymerase chain reaction (PCR) test results …
mortality by different age groups and polymerase chain reaction (PCR) test results …
Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury
Previous work indicates that SARS-CoV-2 virus entry proteins angiotensin-converting
enzyme 2 (ACE-2) and the cell surface transmembrane protease serine 2 (TMPRSS-2) are …
enzyme 2 (ACE-2) and the cell surface transmembrane protease serine 2 (TMPRSS-2) are …
Feminising hormone therapy reduces testicular ACE‐2 receptor expression: Implications for treatment or prevention of COVID‐19 infection in men
JM Masterson, C Bui, Y Zhang, X Yuan, C Huynh… - Andrologia, 2021 - Wiley Online Library
It has been proposed that men hospitalised with COVID‐19 be treated with oestrogen or
progesterone to improve COVID‐19 outcomes. Transgender women (male‐to‐female) are …
progesterone to improve COVID‐19 outcomes. Transgender women (male‐to‐female) are …
EXOGENOUS Sex Hormones and Sex Hormone Receptor Modulators in COVID‐19: Rationale and Clinical Pharmacology Considerations
Male patients with coronavirus disease 2019 (COVID‐19) fare much worse than female
patients in COVID‐19 severity and mortality according to data from several studies. Because …
patients in COVID‐19 severity and mortality according to data from several studies. Because …
A influência dos hormônios sexuais na resposta imunológica da COVID-19: uma revisão integrativa
DM dos Reis, LPSR Gama, IA Teixeira… - Revista Eletrônica …, 2021 - acervomais.com.br
Objetivo: Avaliar as diferenças sexuais na resposta imunológica a COVID-19 relacionadas a
influência hormonal. Métodos: Foi realizada uma pesquisa bibliográfica, de caráter …
influência hormonal. Métodos: Foi realizada uma pesquisa bibliográfica, de caráter …