Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Preclinical studies indicate an age-associated accumulation of senescent cells across
multiple organ systems. Emerging evidence suggests that tau protein accumulation, which …

Glioblastomas (GBM) are routinely treated with ionizing radiation (IR) but inevitably recur
and develop therapy resistance. During treatment, the tissue surrounding tumors is also …

Older age and underlying conditions such as diabetes/obesity or immunosuppression are
leading host risk factors for developing severe complications from COVID‐19 infection. The …

Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and
can express a pro-inflammatory, tissue-destructive senescence-associated secretory …

Background α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious
changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of …

The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …

Aging can cause morphological transformation in human microglia indicative of cell
senescence, termed microglial dystrophy. However, cellular senescence is characterized by …

Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …