Arterial stiffness and cardiovascular risk in hypertension

P Boutouyrie, P Chowienczyk, JD Humphrey… - Circulation …, 2021 - Am Heart Assoc
Arterial stiffness, a leading marker of risk in hypertension, can be measured at material or
structural levels, with the latter combining effects of the geometry and composition of the …

ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways

AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

N Sayed, Y Huang, K Nguyen, Z Krejciova-Rajaniemi… - Nature aging, 2021 - nature.com
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …

[HTML][HTML] Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms

JR Petrie, TJ Guzik, RM Touyz - Canadian Journal of Cardiology, 2018 - Elsevier
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as
frequent in patients with diabetes compared with those who do not have diabetes. Moreover …

[HTML][HTML] Oxidative stress: a unifying paradigm in hypertension

RM Touyz, FJ Rios, R Alves-Lopes, KB Neves… - Canadian journal of …, 2020 - Elsevier
The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension

IAM Brown, L Diederich, ME Good… - … , and vascular biology, 2018 - Am Heart Assoc
Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

The role of vascular smooth muscle cells in arterial remodeling: focus on calcification-related processes

A Jaminon, K Reesink, A Kroon… - International journal of …, 2019 - mdpi.com
Arterial remodeling refers to the structural and functional changes of the vessel wall that
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …

Effect of different classes of antihypertensive drugs on endothelial function and inflammation

IVG Silva, RC de Figueiredo, DRA Rios - International journal of …, 2019 - mdpi.com
Hypertension is characterized by structural and functional changes in blood vessels that
travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction …

A role for advanced glycation end products in molecular ageing

K Zgutka, M Tkacz, P Tomasiak… - International journal of …, 2023 - mdpi.com
Ageing is a composite process that involves numerous changes at the cellular, tissue, organ
and whole-body levels. These changes result in decreased functioning of the organism and …