[HTML][HTML] SARS-CoV-2: an overview of the genetic profile and vaccine effectiveness of the five variants of concern
R Dumache, A Enache, I Macasoi, CA Dehelean… - Pathogens, 2022 - mdpi.com
With the onset of the COVID-19 pandemic, enormous efforts have been made to understand
the genus SARS-CoV-2. Due to the high rate of global transmission, mutations in the viral …
the genus SARS-CoV-2. Due to the high rate of global transmission, mutations in the viral …
[HTML][HTML] Antivirals for broader coverage against human coronaviruses
Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a
genome that is 27–31 kbases in length. Critical genes include the spike (S), envelope (E) …
genome that is 27–31 kbases in length. Critical genes include the spike (S), envelope (E) …
[HTML][HTML] Efficacy of Kan Jang® in Patients with Mild COVID-19: Interim Analysis of a Randomized, Quadruple-Blind, Placebo-Controlled Trial
L Ratiani, E Pachkoria, N Mamageishvili, R Shengelia… - Pharmaceuticals, 2022 - mdpi.com
Kan Jang®, the fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and
Eleutherococcus senticosus (Rupr. & Maxim.) Maxim extracts, is a herbal medicinal product …
Eleutherococcus senticosus (Rupr. & Maxim.) Maxim extracts, is a herbal medicinal product …
EpiMed Coronabank Chemical Collection: Compound selection, ADMET analysis, and utilisation in the context of potential SARS-CoV-2 antivirals
E Pitsillou, RC Beh, JJ Liang, TS Tang, X Zhou… - Journal of Molecular …, 2023 - Elsevier
Antiviral drugs are important for the coronavirus disease 2019 (COVID-19) response, as
vaccines and antibodies may have reduced efficacy against severe acute respiratory …
vaccines and antibodies may have reduced efficacy against severe acute respiratory …
[HTML][HTML] Efficacy of Kan Jang® in Patients with Mild COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial
L Ratiani, E Pachkoria, N Mamageishvili, R Shengelia… - Pharmaceuticals, 2023 - mdpi.com
Background and aim. This study aimed to assess the efficacy of the treatment of Kan Jang®,
a fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and …
a fixed combination of Andrographis paniculata (Burm. F.) Wall. ex. Nees and …
[HTML][HTML] How deep learning in antiviral molecular profiling identified anti-SARS-CoV-2 inhibitors
M Ali, IH Park, J Kim, G Kim, J Oh, JS You, J Kim… - Biomedicines, 2023 - mdpi.com
The integration of artificial intelligence (AI) into drug discovery has markedly advanced the
search for effective therapeutics. In our study, we employed a comprehensive computational …
search for effective therapeutics. In our study, we employed a comprehensive computational …
Combination therapy with remdesivir and immunomodulators improves respiratory status in COVID‐19: A retrospective study
Y Kojima, S Nakakubo, K Kamada… - Journal of Medical …, 2022 - Wiley Online Library
Immunomodulators (tocilizumab/baricitinib) improve outcomes of coronavirus disease 2019
(COVID‐19) patients, but the synergistic effect of remdesivir is unknown. The effect of …
(COVID‐19) patients, but the synergistic effect of remdesivir is unknown. The effect of …
[HTML][HTML] Effect of remdesivir on mortality and the need for mechanical ventilation among hospitalized patients with COVID-19: real-world data from a resource-limited …
R Metchurtchlishvili, N Chkhartishvili, A Abutidze… - International Journal of …, 2023 - Elsevier
Objectives Georgia introduced remdesivir for the treatment of COVID-19 in December 2020.
We evaluated the real-world effect of remdesivir on mortality and the need for mechanical …
We evaluated the real-world effect of remdesivir on mortality and the need for mechanical …
[HTML][HTML] Lessons we learned during the past four challenging years in the COVID-19 era: pharmacotherapy, long COVID complications, and vaccine development
P Ghasemiyeh, S Mohammadi-Samani - Virology Journal, 2024 - Springer
About four years have passed since the detection of the first cases of COVID-19 in China.
During this lethal pandemic, millions of people have lost their lives around the world. Since …
During this lethal pandemic, millions of people have lost their lives around the world. Since …
[HTML][HTML] The effect of remdesivir on mortality and the outcome of patients with COVID‐19 in intensive care unit: A case–control study
M Amirizadeh, A Kharazmkia, G Azimi - Health Science Reports, 2023 - ncbi.nlm.nih.gov
In 2002, severe acute respiratory syndrome (SARS) first appeared in China. It quickly spread
worldwide within 3 months, resulting in the first pandemic of the twenty‐first century with a …
worldwide within 3 months, resulting in the first pandemic of the twenty‐first century with a …