The acid sphingomyelinase/ceramide system in COVID-19
J Kornhuber, N Hoertel, E Gulbins - Molecular Psychiatry, 2022 - nature.com
Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …
Inhibitors of sars-cov-2 plpro
The emergence of SARS-CoV-2 causing the COVID-19 pandemic, has highlighted how a
combination of urgency, collaboration and building on existing research can enable rapid …
combination of urgency, collaboration and building on existing research can enable rapid …
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
M Hoffmann, H Hofmann-Winkler, JC Smith… - …, 2021 - thelancet.com
Background Antivirals are needed to combat the COVID-19 pandemic, which is caused by
SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS …
SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS …
Effect of early treatment with hydroxychloroquine or lopinavir and ritonavir on risk of hospitalization among patients with COVID-19: the TOGETHER randomized …
Importance Data on the efficacy of hydroxychloroquine or lopinavir-ritonavir for the treatment
of high-risk outpatients with COVID-19 in developing countries are needed. Objective To …
of high-risk outpatients with COVID-19 in developing countries are needed. Objective To …
Phytochemicals-based targeting RdRp and main protease of SARS-CoV-2 using docking and steered molecular dynamic simulation: A promising therapeutic …
The ongoing COVID-19 pandemic has affected millions of people worldwide and caused
substantial socio-economic losses. Few successful vaccine candidates have been approved …
substantial socio-economic losses. Few successful vaccine candidates have been approved …
A comprehensive review about the molecular structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Insights into natural products against …
In 2019, the world suffered from the emergence of COVID-19 infection, one of the most
difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have …
difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have …
[HTML][HTML] Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study
Background Development of an effective antiviral drug for Coronavirus Disease 2019
(COVID-19) is a global health priority. Although several candidate drugs have been …
(COVID-19) is a global health priority. Although several candidate drugs have been …
Phase 1 trial of a candidate recombinant virus-like particle vaccine for Covid-19 disease produced in plants
BJ Ward, P Gobeil, A Séguin, J Atkins, I Boulay… - MedRxiv, 2020 - medrxiv.org
Longer Abstract Background The stabilized prefusion form of the SARS-CoV-2 spike protein
is produced by transient expression in Nicotiana benthamiana. The trimeric spike …
is produced by transient expression in Nicotiana benthamiana. The trimeric spike …
A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 …
T Kinoshita, M Shinoda, Y Nishizaki, K Shiraki, Y Hirai… - BMC medicine, 2022 - Springer
Background In vitro drug screening studies have indicated that camostat mesilate (FOY-305)
may prevent SARS-CoV-2 infection into human airway epithelial cells. This study was …
may prevent SARS-CoV-2 infection into human airway epithelial cells. This study was …
Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs
OA Badary - The pharmacogenomics journal, 2021 - nature.com
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …