In-depth analysis of physiologically based pharmacokinetic (PBPK) modeling utilization in different application fields using text mining tools
In the past decade, only a small number of papers have elaborated on the application of
physiologically based pharmacokinetic (PBPK) modeling across different areas. In this …
physiologically based pharmacokinetic (PBPK) modeling across different areas. In this …
Utility of chimeric mice with humanized liver for predicting human pharmacokinetics in drug discovery: comparison with in vitro–in vivo extrapolation and allometric …
Y Naritomi, S Sanoh, S Ohta - Biological and Pharmaceutical Bulletin, 2019 - jstage.jst.go.jp
Predicting human pharmacokinetics (PK) such as clearance (CL) and volume of distribution
(Vd) is a critical component of drug discovery. These predictions are mainly performed by in …
(Vd) is a critical component of drug discovery. These predictions are mainly performed by in …
Prediction of cyclosporin-mediated drug interaction using physiologically based pharmacokinetic model characterizing interplay of drug transporters and enzymes
Y Yang, P Li, Z Zhang, Z Wang, L Liu, X Liu - International journal of …, 2020 - mdpi.com
Uptake transporter organic anion transporting polypeptides (OATPs), efflux transporters (P-
gp, BCRP and MRP2) and cytochrome P450 enzymes (CYP450s) are widely expressed in …
gp, BCRP and MRP2) and cytochrome P450 enzymes (CYP450s) are widely expressed in …
Quantifying the limits of CAR T-cell delivery in mice and men
LV Brown, EA Gaffney, A Ager… - Journal of the Royal …, 2021 - royalsocietypublishing.org
CAR (Chimeric Antigen Receptor) T cells have demonstrated clinical success for the
treatment of multiple lymphomas and leukaemias, but not for various solid tumours, despite …
treatment of multiple lymphomas and leukaemias, but not for various solid tumours, despite …
In vitro and in vivo bioequivalence study of 3D-printed instant-dissolving levetiracetam tablets and subsequent personalized dosing for Chinese children based on …
X Li, E Liang, X Hong, X Han, C Li, Y Wang, Z Wang… - Pharmaceutics, 2021 - mdpi.com
Recently, the development of Binder Jet 3D printing technology has promoted the research
and application of personalized formulations, which are especially useful for children's …
and application of personalized formulations, which are especially useful for children's …
Physiologically‐based pharmacokinetic modeling for optimal dosage prediction of quinine coadministered with ritonavir‐boosted lopinavir
T Saeheng, K Na‐Bangchang… - Clinical …, 2020 - Wiley Online Library
The coformulated lopinavir/ritonavir significantly reduces quinine concentration in healthy
volunteers due to potential drug–drug interactions (DDIs). However, DDI information in …
volunteers due to potential drug–drug interactions (DDIs). However, DDI information in …
Predicting pharmacokinetics of a tenofovir alafenamide subcutaneous implant using physiologically based pharmacokinetic modelling
RKR Rajoli, ZR Demkovich, C Flexner… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Long-acting (LA) administration using a subcutaneous (sc) implant presents opportunities to
simplify administration of antiretroviral drugs, improve pharmacological profiles, and …
simplify administration of antiretroviral drugs, improve pharmacological profiles, and …
In Silico Prediction of Andrographolide Dosage Regimens for COVID-19 Treatment
T Saeheng, J Karbwang… - The American Journal of …, 2022 - World Scientific
Andrographolide (APE) has been used for COVID-19 treatment in various clinical settings in
South-East Asia due to its benefits on reduction of viral clearance and prevention of disease …
South-East Asia due to its benefits on reduction of viral clearance and prevention of disease …
[HTML][HTML] Investigating the uncertainty of prediction accuracy for the application of physiologically based pharmacokinetic models to animal-free risk assessment of …
S Terasaka, A Hayashi, Y Nukada… - Regulatory Toxicology and …, 2022 - Elsevier
Physiologically based pharmacokinetic (PBPK) models are considered useful tools in
animal-free risk assessment. To utilize PBPK models for risk assessment, it is necessary to …
animal-free risk assessment. To utilize PBPK models for risk assessment, it is necessary to …
Analysis of cellular kinetic models suggest that physiologically based model parameters may be inherently, practically unidentifiable
LV Brown, MC Coles, M McConnell… - … of Pharmacokinetics and …, 2022 - Springer
Physiologically-based pharmacokinetic and cellular kinetic models are used extensively to
predict concentration profiles of drugs or adoptively transferred cells in patients and …
predict concentration profiles of drugs or adoptively transferred cells in patients and …