Role of plant-derived active constituents in cancer treatment and their mechanisms of action

AW Khan, M Farooq, M Haseeb, S Choi - Cells, 2022 - mdpi.com
Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …

Targeting the interplay of autophagy and ROS for cancer therapy: An updated overview on phytochemicals

L Dong, J He, L Luo, K Wang - Pharmaceuticals, 2023 - mdpi.com
Autophagy is an evolutionarily conserved self-degradation system that recycles cellular
components and damaged organelles, which is critical for the maintenance of cellular …

[HTML][HTML] Erianin induces ferroptosis of renal cancer stem cells via promoting ALOX12/P53 mRNA N6-methyladenosine modification

H Shen, Z Geng, X Nie, T Liu - Journal of Cancer, 2023 - ncbi.nlm.nih.gov
Renal cell carcinoma (RCC) is the most common type of primary renal parenchymal
malignancy in adults, with a high degree of malignancy and poor prognosis. Human renal …

Erianin: a phytoestrogen with therapeutic potential

G Li, H Zhang, H Lai, G Liang, J Huang… - Frontiers in …, 2023 - frontiersin.org
Erianin, a phytoestrogen with therapeutic potential, is one of the major active components of
Dendrobll caulis. Erianin has a variety of pharmacological effects, such as anti-tumor, anti …

Erianin inhibits human lung cancer cell growth via PI3K/Akt/mTOR pathway in vitro and in vivo

H Zhang, X Xie, G Li, J Chen, M Li, X Xu… - Phytotherapy …, 2021 - Wiley Online Library
Erianin is a small‐molecule compound that is isolated from Dendrobium chrysotoxum Lindl.
In recent years, it has been found to have evident antitumor activity in various cancers, such …

Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway

Y Xu, R Fang, J Shao, Z Cai - Bioscience reports, 2021 - portlandpress.com
Background: Triple-negative breast cancer (TNBC) is a refractory subtype of breast cancer,
25–30% of which have dysregulation in the PI3K/AKT pathway. The present study …

Recent advances of antitumor leading compound Erianin: Mechanisms of action and structural modification

L Ma, M Li, Y Zhang, K Liu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Erianin, a bioactive compound extracted from Dendrobium, a traditional Chinese medicine,
exhibits remarkable anti-cancer properties through diverse molecular mechanisms and has …

Erianin induces apoptosis and autophagy in oral squamous cell carcinoma cells

YT Chen, MJ Hsieh, PN Chen, CJ Weng… - The American journal …, 2020 - World Scientific
Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths
worldwide. It has a very poor prognosis with over a 5-year survival rate of only 50%. Thus, it …

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits bladder cancer cell growth via the mitochondrial apoptosis and JNK pathways

Q Zhu, Y Sheng, W Li, J Wang, Y Ma, B Du… - Toxicology and applied …, 2019 - Elsevier
Erianin, a component extracted from the traditional Chinese herbal medicine Dendrobium,
has shown significant anti-tumour activity in various cancers but not in bladder cancer. In this …

Erianin suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK MAPK signaling pathways

L Yang, Y Hu, G Zhou, Q Chen, Z Song - Bioscience reports, 2020 - portlandpress.com
Background: Hepatocellular carcinoma (HCC) is the dominant pathological type of primary
liver cancer and no effective methods are available for its treatment. Erianin is a natural …